Can RapidTEG Accelerate the Search for Coagulopathies in the Patient With Multiple Injuries?
Can RapidTEG Accelerate the Search for Coagulopathies in the Patient With Multiple Injuries?
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DOI：
10.1097/ta.0b013e31819d3caf
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发表时间：
2009-04-01
影响因子：
--
通讯作者：
Exadaktylos, Aristonenis K.
中科院分区：
文献类型：
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作者：
Jeger, Victor;Zimmermann, Heinz;Exadaktylos, Aristonenis K.
假设：早期识别凝血功能障碍可能会改善多发伤患者的护理。快速血栓弹力图（RapidTEG）是血栓弹力图（TEG）的一种新变体，其中通过加入蛋白质组织因子来启动凝血。比较了TEG-RapidTEG和常规TEG的两种变体的凝血动力学和测量时间，其中。用高岭土引发凝结。对20名多发性损伤患者的血液样本进行了测量。RapidTEG结果还与常规的凝血测量结果进行了比较。RapidTEG试验的平均时间为19.2 +/- 3.1分钟（平均值+/- SD），相比之下，高岭土TEG为29.9 +/- 4.3分钟，常规凝血试验为34.1 +/- 14.5分钟。RapidTEG试验的平均时间为30.8 +/- 5.72分钟，相比之下，高岭土TEG试验的平均时间为41.5 +/- 5.66分钟，常规凝血试验的平均时间为64.9 +/- 18.8分钟-从患者进入复苏室到获得结果。RapidTEG结果与高岭土TEG和常规凝血试验的结果之间存在显着相关性。RapidTEG是最快速的检测方法，可为多发性损伤患者的凝血功能障碍提供可靠的信息。这对改善病人护理有意义。
Hypothesis: Early recognition of coagulopathy may improve the care of patients with multiple injuries. Rapid thrombelastography (RapidTEG) is a new variant of thrombelastography (TEG), in which coagulation is initiated by the addition of protein tissue factor. The kinetics of coagulation and the times of measurement were compared for two variants of TEG-RapidTEG and conventional TEG, in which. coagulation was initiated with kaolin. The measurements were performed on blood samples from 20 patients with multiple injuries. The RapidTEG results were also compared with conventional measurements of blood coagulation. The mean time for the RapidTEG test was 19.2 +/- 3.1 minutes (mean +/- SD), in comparison with 29.9 +/- 4.3 minutes for kaolin TEG and 34.1 +/- 14.5 minutes for conventional coagulation tests. The mean time for the RapidTEG test was 30.8 +/- 5.72 minutes, in comparison with 41.5 +/- 5.66 minutes for kaolin TEG and 64.9 +/- 18.8 for conventional coagulation tests-measured from admission of the patients to the resuscitation bay until the results were available. There were significant correlations between the RapidTEG results and those from kaolin TEG and conventional coagulation tests. RapidTEG is the most rapid available test for providing reliable information on coagulopathy in patients with multiple injuries. This has implications for improving patient care.