APOMORPHINE DISRUPTS THE INHIBITION OF ACOUSTIC STARTLE INDUCED BY WEAK PREPULSES IN RATS
APOMORPHINE DISRUPTS THE INHIBITION OF ACOUSTIC STARTLE INDUCED BY WEAK PREPULSES IN RATS
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DOI：
10.1007/bf02245735
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发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
GEYER, MA
中科院分区：
文献类型：
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作者：
DAVIS, M;MANSBACH, RS;GEYER, MA
在两个不同的实验室进行的单独实验评估了预脉冲强度在阿波啡减少声惊吓反应的预脉冲抑制能力中的重要性。大鼠分别在脉冲前70 ~ 85 ~ 90 dB的刺激100 ms后单独或单独接受噪声刺激。在整个测试过程中，背景噪声保持在65 dB。在两个实验中，当脉冲前刺激不超过背景10 dB时，阿波啡显著降低了脉冲前抑制的绝对幅度。当脉冲前刺激强度较大时，阿波啡对脉冲前抑制作用不显著。因此，阿波啡不干扰实际上介导预脉冲抑制的抑制过程，但似乎影响预脉冲的可检测性。
Separate experiments conducted in two different laboratories assessed the importance of the prepulse intensity in the ability of apomorphine to reduce prepulse inhibition of acoustic startle responses. Rats were presented with noise bursts alone or noise bursts 100 ms after presentation of prepulse stimuli ranging from 70 to 85 ro 90 dB. Throughout testing, the background noise was maintained at 65 dB. In both laboratories, apomorphine markedly decreased the absolute magnitude of prepulse inhibition when the prepulse stimuli were not more than 10 dB above the background. With more intense prepulse stimuli, apomorphine had no significant effect on prepulse inhibition. Hence, apomorphine does not interfere with the inhibitory process which actually mediates prepulse inhibition, but appears to affect the detectability of the prepulse.