Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies
Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies
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DOI：
10.1016/j.neurobiolaging.2019.04.006
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发表时间：
2019-08-01
影响因子：
4.2
通讯作者：
Sexton, Claire E.
中科院分区：
文献类型：
--
作者：
Wassenaar, Thomas M.;Yaffe, Kristine;Sexton, Claire E.
人们对可能调节白色物质（WM）分解的因素越来越感兴趣，因此，与年龄相关的认知和行为缺陷。最近的扩散张量成像研究已经研究了这些因素与WM微结构的关系。这篇综述总结了WM微观结构和公认的可改变因素之间关系的证据，包括听力损失，高血压，糖尿病，肥胖，吸烟，抑郁症状，身体（在）活动，社会隔离，以及睡眠障碍，饮食，认知训练和冥想。目前的横断面证据表明，WM完整性丧失（较低的各向异性分数和较高的平均扩散率）与高血压、肥胖、糖尿病和吸烟之间存在明确的联系;这种关系似乎适用于听力损失、社交孤立、抑郁症状和睡眠障碍。另一方面，体力活动，认知训练，饮食和冥想可能会保护WM老化。治疗的危险因素的横断面研究的初步证据表明，修改的因素可以减缓WM微观结构的负面影响。需要对这些文献进行仔细的干预研究，以便为今后的公共卫生举措做出贡献。(C)2019年，任作家。爱思唯尔公司出版
There is increasing interest in factors that may modulate white matter (WM) breakdown and, consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor imaging studies have examined the relationship of such factors with WM microstructure. This review summarizes the evidence regarding the relationship between WM microstructure and recognized modifiable factors, including hearing loss, hypertension, diabetes, obesity, smoking, depressive symptoms, physical (in) activity, and social isolation, as well as sleep disturbances, diet, cognitive training, and meditation. Current cross-sectional evidence suggests a clear link between loss of WM integrity (lower fractional anisotropy and higher mean diffusivity) and hypertension, obesity, diabetes, and smoking; a relationship that seems to hold for hearing loss, social isolation, depressive symptoms, and sleep disturbances. Physical activity, cognitive training, diet, and meditation, on the other hand, may protect WM with aging. Preliminary evidence from cross-sectional studies of treated risk factors suggests that modification of factors could slow down negative effects on WM microstructure. Careful intervention studies are needed for this literature to contribute to public health initiatives going forward. (C) 2019 The Authors. Published by Elsevier Inc.