Exploring the Relationship Between Body Mass Index and Positive Symptom Severity in Persons at Clinical High Risk for Psychosis.
Exploring the Relationship Between Body Mass Index and Positive Symptom Severity in Persons at Clinical High Risk for Psychosis.
复制标题
DOI：
10.1097/nmd.0000000000000736
复制
发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Girgis R
中科院分区：
文献类型：
--
作者：
Caravaggio F;Brucato G;Kegeles LS;Lehembre-Shiah E;Arndt LY;Colibazzi T;Girgis R
代谢健康和阳性症状严重程度已在精神分裂症（SCZ）中进行了调查，但在临床高危（CHR）患者中尚未进行调查。我们假设CHR患者的身体质量指数（BMI）越大，阳性症状越少。我们在接受以下治疗的CHR患者中研究了这种关系：i)未接受精神药物治疗（n=58）， ii)接受抗精神病药物治疗（n=14），或iii)接受抗抑郁药物治疗而不接受抗精神病药物治疗（n=10）。在未服药的CHR患者中，我们发现BMI与阳性症状之间没有关系，其中大多数患者的BMI范围在20-30之间。然而，在服用抗抑郁药或抗精神病药的CHR患者的小样本中，BMI与阳性症状呈负相关。虽然这些初步发现可能不够有力，但它们为阐明CHR患者的代谢健康、神经化学和症状严重程度之间的关系提供了初步的步骤。
Metabolic health and positive symptom severity has been investigated in schizophrenia (SCZ), but not in clinical high-risk (CHR) patients. We hypothesized that greater body mass index (BMI) in CHR patients would be related to less positive symptoms. We examined this relationship in CHR patients being treated with, i) no psychotropic medications (n=58), ii) an antipsychotic (n=14), or iii) an antidepressant without an antipsychotic (n=10). We found no relationship between BMI and positive symptoms in un-medicated CHR patients, the majority of whom had a narrow BMI range between 20–30. However, in the smaller sample of CHR patients taking an antidepressant or antipsychotic, BMI was negatively correlated with positive symptoms. While potentially underpowered, these preliminary findings provide initial steps in elucidating the relationships between metabolic health, neurochemistry, and symptom severity in CHR patients.