Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa
Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa
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DOI：
10.1691/ph.2010.9870
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发表时间：
2010-08-01
期刊：
影响因子：
1.6
通讯作者：
Yun-Choi, Hye Sook
中科院分区：
文献类型：
--
作者：
Koo, Yean Kyoung;Kim, Jeong Mi;Yun-Choi, Hye Sook
两个芍药科成员的根在韩国、中国和日本长期被用作传统药物。芍药的干根和牡丹皮的干根皮分别以传统名称芍药根和牡丹皮使用。黄芪和厚朴都被用作心血管疾病的补救措施，用于改善血液循环或其他用途。据推测，这两种植物可能含有共同的活性成分，有助于抑制血液凝固和/或血小板聚集。18种化合物，据报道存在于两种植物药物中，评价了它们对血小板聚集和血液凝固的影响。发现丹皮酚（5）、芍药苷（9）、苯甲酰基芍药苷（11）和苯甲酰氧基芍药苷（12）是主要的常见活性成分，并且它们通过对血小板聚集和血液凝固的抑制作用共同有助于改善血液循环。此外，没食子酸甲酯（4）、（+）-儿茶素（7）、芍药苷元（8）、没食子酰芍药苷（13）和胡萝卜苷（16）也可通过抑制血小板聚集和/或血液凝固而参与改善血液循环。
The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively. Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation. Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), paeoniflorigenone (8), galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.