Discharge characteristics of vestibular and saccade neurons in the rostral midbrain of alert cats.
Discharge characteristics of vestibular and saccade neurons in the rostral midbrain of alert cats.
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警觉猫中脑头端前庭和眼跳神经元的放电特征。
DOI：
10.1152/jn.1995.73.6.2129
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kaneko,CR
中科院分区：
文献类型：
--
作者：
Fukushima,K;Ohashi,T;Fukushima,J;Kaneko,CR
1. Cajal间质核（INC）参与眼球垂直运动的产生。为了进一步探索INC参与眼球运动的神经基础，我们研究了警觉性猫前庭刺激和扫视放电的吻侧中脑神经元的放电特征。我们分析了75个前庭和扫视神经元（VSNs）在俯仰旋转过程中表现出特征性放电。其中，50个脑区在上升慢相活动逐渐增加，在下降快相动作电位爆发。其余25个细胞表现出相反的反应模式：在下行慢速期活动逐渐增加，在上升音调诱导的上行快速期活动爆发。我们将这些细胞分别分为向下的vsn和向上的vsn。观察电刺激对侧前庭神经对13个下行vsn和2个上行vsn的影响；它们都在短潜伏期内被激活。2. 所有垂直VSNs也表现出与自发扫视相关的爆发活动。在扫视和前庭快速阶段，脉冲的首选方向总是相同的。爆发活动的开始比快速眼动的开始平均早35 +/- 14 ms（平均±SD）。在其他方向的快速眼球运动中，这些细胞中的许多也表现出不一致的爆发，并且爆发通常在扫视开始后开始。一半向上的视神经网络在向下快速眼球运动时显示出活动暂停。3. 尽管相关系数通常为0.5-0.6，但在研究的一半垂直VSNs中，首选方向的爆发参数与眼跳参数相关。4. 所有垂直VSNs均有不规则的静息活动。一半向下的VSNs显示出与爆发活动的首选方向相反的眼位敏感性，但仅限于在扫视之前和之后的短时间内分析。5. 在几个垂直平面的正弦旋转过程中，所有向下的VSNs都接收到来自对侧前管的强兴奋输入。4个向上的VSNs中有3个接受对侧后椎管兴奋；例外者接受同侧后椎管刺激。（摘要删节为400字）
1. The interstitial nucleus of Cajal (INC) is involved in generation of vertical eye movements. To further explore the neural substrates of INC involvement in eye movements, we examined the discharge characteristics of neurons in the rostral midbrain that discharge for vestibular stimulation and saccades in alert cats. We analyzed 75 vestibular and saccade neurons (VSNs) that showed characteristic discharge during pitch rotation. Of these, 50 exhibited gradually increasing activity during upward slow phases and burst of action potentials during downward fast phases induced by downward pitch. The remaining 25 cells showed the opposite response pattern: gradually increasing activity during downward slow phases and a burst during upward fast phases induced by upward pitch. We classified these cells as downward VSNs and upward VSNs, respectively. The effects of electrical stimulation of the contralateral vestibular nerve were tested for 13 downward VSNs and 2 upward VSNs; all of them were activated at short latencies. 2. All vertical VSNs also showed burst activity associated with spontaneous saccades. The preferred direction for the burst was always the same for saccades and vestibular fast phases. The onset of burst activity preceded the onset of fast eye movement by an average of 35 +/- 14 ms (mean +/- SD). During fast eye movement in other directions, many of these cells also showed an inconsistent burst and the burst often began after the onset of saccades. Half of the upward VSNs examined showed a pause in activity during downward fast eye movement. 3. Burst parameters in the preferred directions were correlated with saccade parameters in half of the vertical VSNs examined, although the correlation coefficients were typically 0.5-0.6. 4. All vertical VSNs had irregular resting activity. Half of the downward VSNs examined showed eye-position sensitivity toward the direction opposite to the preferred direction for the burst activity but only if the period of analysis was restricted to discharge shortly before and after saccades. 5. All downward VSNs examined during sinusoidal rotation in several vertical planes received strong excitatory input from the contralateral anterior canal. Three of four upward VSNs examined received contralateral posterior canal excitation; the exception received ipsilateral posterior canal excitation.(ABSTRACT TRUNCATED AT 400 WORDS)