Parsing differences in amygdala volume among individuals with and without social and generalized anxiety disorders across the lifespan.
Parsing differences in amygdala volume among individuals with and without social and generalized anxiety disorders across the lifespan.
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DOI：
10.1016/j.jpsychires.2020.05.027
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发表时间：
2020-05
影响因子：
4.8
通讯作者：
Jennifer H. Suor;Jagan Jimmy;Christopher S. Monk;K. L. Phan;Katie L. Burkhouse
中科院分区：
文献类型：
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作者：
Jennifer H. Suor;Jagan Jimmy;Christopher S. Monk;K. L. Phan;Katie L. Burkhouse
杏仁核(AMG)的结构差异与焦虑有关，并在患有广泛性(GAD)和社交焦虑(SAD)障碍的个体中观察到。研究结果喜忧参半，可能是因为很少有研究检查广泛性AD和SAD之间的差异，测试共病，或检查与年龄相关的差异。我们测试了患有和不患有SAD和GAD的成年人和年轻人的AMG音量差异。参与者(N = 242；年龄7-60岁)完成了核磁共振扫描、诊断性访谈和焦虑症状测量。诊断性访谈分为：1)典型发育期(TD；n= 91)；2)广泛性AD(n= 53)；3)SAD(n= 35)；4)SAD/GAD共病(n= 63)。我们使用协方差分析和Bonferroni校正来检查AMG体积的组间差异。与TD组相比，SAD组和SAD/GAD组的双侧AMG体积增大。GAD组和TD组的AMG大小无明显差异。与GAD组相比，SAD组的右侧AMG大小较大，但SAD/GAD组并存。SAD/GAD组和SAD/GAD组在左AMG体积上与GAD组无差异。SAD和SAD/GAD组双侧AMG大小无差异。线性回归分析表明，AMG体积增大与社交焦虑程度有关，而与广泛性焦虑症状严重程度无关。年龄与AMG量无关，也不影响任何组或症状的影响。未来的纵向研究应该检查较大的AMG体积是否是SAD的一个独特的生物标志物。
Structural differences in the amygdala (AMG) are implicated in anxiety and observed among individuals with generalized (GAD) and social anxiety (SAD) disorders. Findings have been mixed, perhaps because studies rarely examine differences between GAD and SAD, test comorbidity, or examine age-related differences. We tested AMG volume differences among a sample of adults and youth with/without SAD and GAD. Participants (N = 242; ages 7–60 years) completed an MRI scan, diagnostic interviews, and anxiety symptom measures. Groups were formed from diagnostic interviews: 1) Typically developing (TD;n= 91); 2) GAD (n= 53); 3) SAD (n= 35); and 4) comorbid SAD/GAD (n= 63). We used analysis of covariance with a bonferroni correction to examine group differences in AMG volume. The SAD and comorbid SAD/GAD groups exhibited increased bilateral AMG volume compared to the TD group. GAD and TD groups did not differ from each other in AMG size. The SAD, but not the comorbid SAD/GAD group, displayed greater right AMG size relative to the GAD group. SAD and comorbid SAD/GAD groups did not differ from the GAD group in left AMG volume. SAD and SAD/GAD groups did not exhibit different bilateral AMG size. Linear regression analyses demonstrated that greater social anxiety but not generalized anxiety symptom severity was associated with enlarged AMG volume. Age was not associated with AMG volume and nor did age moderate any group or symptom effects. Future longitudinal studies should examine whether larger AMG volume is a unique biomarker for SAD across the lifespan.