Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: Its implication in carcinogenesis
Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: Its implication in carcinogenesis
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DOI：
10.1016/j.lungcan.2009.02.025
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发表时间：
2009-12-01
期刊：
影响因子：
5.3
通讯作者：
Kitamura, Hitoshi
中科院分区：
文献类型：
--
作者：
Okudela, Koji;Woo, Tetsukan;Kitamura, Hitoshi
本研究调查EGFR突变型肺腺癌（ADC）和KRAS突变型ADC与既往疾病和家族史之间的潜在差异。在检查的153个肿瘤中，33个（21.6%）是EGFR突变的，22个（14.4%）是KRAS突变的。EGFR突变的病例显示男性胃癌患者既往疾病的患病率明显较高（EGFR 3/8（37.5%），KRAS 0/13（0.0%），无突变（无）1/57（1.8%）; Fisher精确检验，P=0.0064）或女性子宫肌瘤（EGFR 8/25（32.0%），KRAS 0/9（0.0%），无3/41（7.3%）; Fisher精确检验，P = 0.0139）。突变和家族史之间没有关联，因此EGFR突变的ADC可能通过与其他人不同的致癌途径发展，但遗传背景似乎不太可能是EGFR突变ADC的决定性易感因素。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
The present study investigated the potential difference between EGFR-mutated lung adenocarcinoma (ADC) and KRAS-mutated ADC in relation to past illness and family history. Among the 153 tumors examined, 33 (21.6%) were EGFR-mutated, and 22 (14.4%) were KRAS-mutated. The EGFR-mutated cases showed a significantly higher prevalence of past illness involving the gastric cancer in males (EGFR 3/8 (37.5%), KRAS 0/13 (0.0%), no mutation (NONE) 1/57 (1.8%); Fisher's exact test, P=0.0064) or uterine myoma in females (EGFR 8/25 (32.0%), KRAS 0/9 (0.0%), NONE 3/41 (7.3%); Fisher's exact test, P = 0.0139). No association between the mutations and family history was found. The EGFR-mutated ADC is therefore likely to develop through a distinct carcinogenetic pathway from the others, but genetic backgrounds seemed unlikely to be determinant predisposing to the EGFR-mutated ADC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.