CYCLIC-AMP LEVELS IN ISCHEMIC AND NON-ISCHAEMIC MYOCARDIUM FOLLOWING CORONARY-ARTERY LIGATION - RELATION TO VENTRICULAR-FIBRILLATION
CYCLIC-AMP LEVELS IN ISCHEMIC AND NON-ISCHAEMIC MYOCARDIUM FOLLOWING CORONARY-ARTERY LIGATION - RELATION TO VENTRICULAR-FIBRILLATION
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DOI：
10.1016/0022-2828(78)90008-1
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发表时间：
1978-01-01
影响因子：
5
通讯作者：
OPIE, LH
中科院分区：
文献类型：
--
作者：
PODZUWEIT, T;DALBY, AJ;OPIE, LH
在开胸犬和狒狒中，通过在结扎后1小时内连续进行心外膜微型活检（10至15 mg湿重），研究了冠状动脉前降支心肌环[c]AMP水平高位和低位结扎的影响。在狒狒心脏缺血区与低结扎有一个晚的cAMP水平的增加，开始约10分钟前的心室颤动的发病。在犬低位结扎有没有这样的增加心肌cAMP在1小时内，并没有发生心室颤动。在狗或狒狒中，在低位结扎的几秒钟内，心肌cAMP水平也没有上升。然而，cAMP升高的缺血区在50%的狗在1至3分钟内的高度结扎，但这种上升之前的组织乳酸的积累，表明cAMP没有发挥作用，在早期激活糖酵解。缺血组织中cAMP的积聚可能易诱发心室颤动。
The effects of high and low ligation of the anterior descending coronary artery myocardial cyclic[c]AMP levels were studied in open-chest dogs and baboons by means of sequential epicardial mini-biopsies (10 to 15 mg wet weight) within 1 h of ligation. In the ischemic zone of baboon hearts with low ligation there was a late increase in the level of cAMP which started about 10 min before the onset of ventricular fibrillation. In dogs with low ligation there was no such increase in myocardial cAMP within 1 h and no occurrence of ventricular fibrillation. There was also no rise of myocardial cAMP levels within seconds of low ligation in dogs or in baboons. However, cAMP was elevated in the ischemic zone in 50% of dogs within 1 to 3 min of high ligation but this rise was preceded by an accumulation of tissue lactate, suggesting that cAMP did not play a role in the early activation of glycolysis. The accumulation of cAMP in ischemic tissue may predispose to ventricular fibrillation.