microRNAs as Developmental Regulators
microRNAs as Developmental Regulators
复制标题
DOI：
10.1101/cshperspect.a008144
复制
发表时间：
2015-07-01
影响因子：
7.2
通讯作者：
Srivastava, Deepak
中科院分区：
文献类型：
--
作者：
Ivey, Kathryn N.;Srivastava, Deepak
miRNA生物学领域相对年轻，但它对我们理解各种细胞功能的调节产生了深远的影响。miRNAs在发育中的重要性已经变得几乎无处不在，miRNAs有助于大多数细胞和器官的发育。虽然miRNAs清楚地交织在已知的控制细胞发育的调控网络中，但它们交叉的特定模式通常是非常独特的，并且巧妙地实现了。经常出现的反馈和前馈循环的主题，以平衡或加强他们影响的基因程序是一个共同的线索。目前，在具有不同miRNA和靶点的器官中发现了许多miRNA作为发育调节剂的例子，而随着我们对这一快速发展的生物学领域的了解越来越多，在小鼠发育的背景下出现了新的、意想不到的主题。
The field of miRNA biology is relatively young, but its impact on our understanding of the regulation of a wide array of cell functions is far-reaching. The importance of miRNAs in development has become nearly ubiquitous, with miRNAs contributing to development of most cells and organs. Although miRNAs are clearly interwoven into known regulatory networks that control cell development, the specific modalities by which they intersect are often quite distinct and cleverly achieved. The frequently emerging theme of feed-back and feed-forward loops to either counterbalance or reinforce the gene programs that they influence is a common thread. Many of these examples of miRNAs as developmental regulators are presently found in organs with different miRNAs and targets, whereas novel, unexpected themes emerge in the context of mouse development as we learn more about this rapidly developing area of biology.