GENES ON CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-19 INVOLVED IN 11Q23 ABNORMALITIES IN ACUTE-LEUKEMIA SHARE SEQUENCE HOMOLOGY AND OR COMMON MOTIFS
GENES ON CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-19 INVOLVED IN 11Q23 ABNORMALITIES IN ACUTE-LEUKEMIA SHARE SEQUENCE HOMOLOGY AND OR COMMON MOTIFS
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DOI：
10.1073/pnas.90.10.4631
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发表时间：
1993-05-15
影响因子：
11.1
通讯作者：
CANAANI, E
中科院分区：
文献类型：
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作者：
NAKAMURA, T;ALDER, H;CANAANI, E
涉及11 q23带的染色体易位与人类急性白血病相关这些易位融合了ALL-1基因，同源的果蝇三胸和位于染色体带11 q23，从各种染色体的基因。我们克隆和测序了AF-4和AF-9基因转录本的cDNA，这些基因分别涉及最常见的染色体异常t（4：11）（q21：q23）和t（9：11）（p22：q23）。序列分析表明AF-9基因蛋白产物与在（11：19）染色体易位中与ALL-1融合的ENL基因编码的蛋白之间具有高度同源性。AF-4、AF-9和ENL蛋白含有核靶向序列以及富含丝氨酸和脯氨酸的区域。富含碱性氨基酸的片段也存在于这三种蛋白质中。这些结果表明与ALL-1多肽融合的不同蛋白质提供了相似的功能结构域。
Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1 gene, homolog of Drosophila trithorax and located at chromosome band 11q23, to genes from a variety of chromosomes. We cloned and sequenced cDNAs derived from transcripts of the AF-4 and AF-9 genes involved in the most common chromosome abnormalities, t(4:11)(q21:q23) and t(9:11)(p22:q23), respectively. Sequence analysis indicates high homology between the AF-9 gene protein product and the protein encoded by the ENL gene fused to ALL-1 in (11:19) chromosome translocations. AF-4, AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains.