Making connections: enhancers in cellular differentiation.
Making connections: enhancers in cellular differentiation.
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DOI：
10.1016/j.tig.2021.10.008
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
J. C. Herrmann;Robert A. Beagrie;J. Hughes
中科院分区：
文献类型：
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作者：
J. C. Herrmann;Robert A. Beagrie;J. Hughes
破译数百种不同细胞类型从单个受精卵中产生形成复杂多细胞生物的过程仍然是生物学研究中最大的挑战之一。已知增强子是细胞类型特异性基因表达的核心，但关于这些基因组元件如何在时间和空间上与其他顺式和反式作用因子相互作用以控制分化和发育过程中的转录活性的许多问题仍未得到解答。在这里，我们回顾了目前对增强子的作用及其相互作用的理解，并强调了通过前所未有的分辨率的实验方法取得的最新进展。
Deciphering the process by which hundreds of distinct cell types emerge from a single zygote to form a complex multicellular organism remains one of the greatest challenges in biological research. Enhancers are known to be central to cell type-specific gene expression, yet many questions regarding how these genomic elements interact both temporally and spatially with other cis- and trans-acting factors to control transcriptional activity during differentiation and development remain unanswered. Here, we review our current understanding of the role of enhancers and their interactions in this context and highlight recent progress achieved with experimental methods of unprecedented resolution.