The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
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DOI：
10.1155/2012/492960
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Ebina, Masahito
中科院分区：
文献类型：
--
作者：
Chiba, Shigeki;Ohta, Hiromitsu;Ebina, Masahito
肺纤维化合并肺气肿（CPFE）于1990年首次报道，但直到最近才被相对低估。虽然肺气肿和纤维化区域的诊断结果都可以通过胸部高分辨率计算机断层扫描（HRCT）检测到，但随着肺气肿病变的增加，进行性纤维化的程度很难评估。在这项研究中，我们假设肺纤维化的生物标志物，表面活性蛋白D（SPD）和KL-6将作为CPFE纤维化病变的良好指标。我们招募了2003年4月至2008年3月在我院通过CT扫描图像诊断为肺气肿和纤维化的46例患者。分析肺功能、综合生理指数（CPI）与血清SP-D、KL-6水平的相关性。我们发现KL-6与% VC、% TLC或CPI之间以及SP-D与% VC或CPI之间存在相关性。有趣的是，发现KL-6和SP-D的组合产物（KL-6xSP-D）与% VC和% TLC或CPI高度相关。这些结果表明，KL-6和SP-D，尤其是SP-D和KL-6的产物，是CPFE患者肺中存在纤维化病变的良好指标。
The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by highresolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SPD), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and % VC, % TLC, or CPI and between SP-D and % VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with % VC and % TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.