Chromosomal localization of a human cDNA containing a DIDS binding domain and demonstrating high homology to yeast omnipotent suppressor 45.
Chromosomal localization of a human cDNA containing a DIDS binding domain and demonstrating high homology to yeast omnipotent suppressor 45.
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含有 DIDS 结合域的人类 cDNA 的染色体定位，并证明与酵母全能抑制因子 45 具有高度同源性。
DOI：
10.1007/bf01233452
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Fuller,GM
中科院分区：
文献类型：
--
作者：
Grenett,HE;Eipers,PG;Kidd,VJ;Bounelis,P;Fuller,GM
我们最近已经确定了一个全长cDNA（TB 3 -1）从人腺癌细胞系T84 cDNA文库，编码47.8 kDa的蛋白质。TB 3 -1与假定的酵母翻译终止因子全能抑制子45具有同一性。使用人-小鼠体细胞板分析，与TB 3 -1 cDNA克隆具有高度同源性的序列家族定位于人染色体5、6、7和X。对一组哺乳动物和鸡基因组DNA的Southern分析表明，TB 3 -1在高等脊椎动物中非常保守。
We recently have identified a full-length cDNA (TB3-1) from a human adenocarcinoma cell line T84 cDNA library that encodes a 47.8-kDa protein. TB3-1 shares identity with the putative yeast translation termination factor omnipotent suppressor 45. Using human-mouse somatic cell panel analysis, a family of sequences with high homology to the TB3-1 cDNA clone were localized to human chromosomes 5, 6, 7, and X. Southern analysis of a panel of mammalian and chicken genomic DNA demonstrates that TB3-1 is well conserved in higher vertebrates.