True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo.
True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo.
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DOI：
10.1002/jbmr.2603
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Wallace JM
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文献类型：
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作者：
Allen MR;McNerny EM;Organ JM;Wallace JM
尽管确定骨骼机械完整性的金标准是机械性能的直接测量，但临床评价长期以来一直依赖于机械性能的替代物来评估骨折风险。近十年前，参考点压痕（RPI）作为一种创新的方法出现，以潜在地评估体内骨的力学性能。从BioDent器械开始，然后是新一代的OsteoProbe，这种RPI技术已经出现在几篇论文中。在这篇综述中，我们概述了这两种设备的技术和一些重要的细节。我们还强调了选择的关键研究，特别是这些设备的体内应用，作为综合2015年技术的一种方式。两份临床报告显示，BioDent机器能够区分骨折与非骨折患者人群，并在临床前研究中检测与传统机械测试量化结果一致的治疗效果。OsteoProbe似乎能够分离临床队列，但缺乏关于测试细节的清晰度，这表明需要使用该机器进行更严格的工作。总的来说，RPI技术已经显示出有希望的结果，但还需要更多的工作来确定其在体内评估机械性能的理论潜力是否可以实现。
Although the gold standard for determining bones’ mechanical integrity is the direct measure of mechanical properties, clinical evaluation has long relied on surrogates of mechanical properties for assessment of fracture risk. Nearly a decade ago, reference point indentation (RPI) emerged as an innovative way to potentially assess mechanical properties of bone in vivo. Beginning with the BioDent device, and then followed by the newer generation OsteoProbe, this RPI technology has emerged in several papers. In this review we overview the technology and some important details about the two devices. We also highlight select key studies, focused specifically on the in vivo application of these devices, as a way of synthesizing where the technology stands in 2015. The BioDent machine has been shown, in two clinical reports, to be able to differentiate fracture versus non-fracture patient populations and in preclinical studies to detect treatment effects that are consistent with those quantified using traditional mechanical tests. The OsteoProbe appears able to separate clinical cohorts yet there exists a lack of clarity regarding details of testing, which suggests more rigorous work needs to be undertaken with this machine. Taken together, RPI technology has shown promising results, yet much more work is needed to determine if its theoretical potential to assess mechanical properties in vivo can be realized.