Insights into how innocuous foods or proteins deserving of immune ignorance can become allergens.
Insights into how innocuous foods or proteins deserving of immune ignorance can become allergens.
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深入了解值得免疫忽视的无害食物或蛋白质如何成为过敏原。
DOI：
10.1172/jci141950
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Borish,Larry
中科院分区：
文献类型：
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作者：
Borish,Larry
过敏性疾病包括食物过敏、过敏性鼻炎和某些形式的哮喘，这些疾病是由于对原本无害的空气过敏原和食物的免疫反应不适当而引起的。在这一期的JCI中，Thouvenot和Roitel等人。探索转录不忠诚作为这些良性蛋白质成为过敏原的能力的基础的机制。一些产生过敏的食物和生物气雾剂含有RNA聚合酶，容易产生RNA缺口，从而导致翻译框架移位。这些移码通常产生阳离子羧基残基，取代疏水氨基酸，并增强MHC结合，导致激发免疫反应的倾向。由这些变异转录本引发的IgE抗体反应稍后可以导致针对天然分子的IgE，也解释了当使用天然蛋白试剂检测时，缺乏特异性IgE的个体可能发生过敏反应的原因。这项研究有可能改变过敏性疾病的诊断和治疗。
Allergic disorders include food allergy, allergic rhinitis, and certain forms of asthma resulting from the inappropriate development of immune responses to otherwise innocuous aeroallergens and foods. In this issue of theJCI, Thouvenot and Roitel et al. explore transcription infidelity as a mechanism that underlies the ability of these benign proteins to become allergens. Some foods and bioaerosols that produce allergies have RNA polymerase with a propensity to generate RNA gaps, thereby causing translational frameshifts. These frameshifts often create cationic carboxy-terminus residues that replace hydrophobic amino acids and have enhanced MHC binding, resulting in the tendency to provoke immune responses. IgE antibody responses initiated by these variant transcripts can later lead to IgE against the native molecule and also explain how anaphylaxis may occur in individuals who lacked specific IgE when tested using native protein reagents. This study has the potential to transform the diagnosis and treatment of allergic disorders.