Vitamin D status and parathyroid hormone in a urban population in Vietnam
Vitamin D status and parathyroid hormone in a urban population in Vietnam
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DOI：
10.1007/s00198-010-1207-4
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Nguyen, T. V.
中科院分区：
文献类型：
--
作者：
Ho-Pham, L. T.;Nguyen, N. D.;Nguyen, T. V.
在越南的这项横断面研究中，成年女性维生素D不足的患病率为46%，成年男性为20%。血清25（OH）D和PTH浓度之间呈线性负相关，但PTH水平稳定时没有25（OH）D的阈值。维生素D不足与健康结果有不良关系。亚洲人群的维生素D状况没有很好的记录。本研究旨在评估维生素D状况及其与甲状旁腺激素的关系在越南population.This横断面研究涉及205名男性和432名女性，年龄在18-87岁，谁是随机抽样的不同地区在胡志明市（越南）根据比例抽样方案。在Roche Elecsys 10100/201系统（Roche Diagnosis Elecsys）上通过电化学发光免疫测定法测量血清25（OH）D和PTH浓度。维生素D不足的定量为血清25（OH）D水平低于30 ng/ml（75 nmol/L）。男性和女性的平均年龄分别为43.8 +/- 18.4岁（平均值+/- SD）和47.7 +/- 17.1岁。男性的平均25（OH）D浓度（36.8 +/- 10.2 ng/mL）显著高于女性（30.1 +/- 5.9; P < 0.0001）。男性维生素D不足的患病率为20%（41/205），明显低于女性（46%，199/432）。年龄、身高和体重是25（OH）D浓度的独立预测因素，这三个因素分别解释了男性和女性25（OH）D变异的15%和5%。血清25（OH）D与PTH浓度呈线性负相关，但PTH水平稳定的25（OH）D阈值不存在，这些数据表明，即使在热带地区，维生素D不足也很常见，女性维生素D不足的风险高于男性。这些数据表明，甲状旁腺素的升高不能作为维生素D缺乏的标志物。
In this cross-sectional study in Vietnam, the prevalence of vitamin D insufficiency was 46% in adult women and 20% in adult men. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued.Vitamin D insufficiency is adversely associated with health outcomes. Vitamin D status in Asian populations is not well documented. This study sought to assess vitamin D status and its relationship to parathyroid hormone in a Vietnamese population.This cross-sectional study involved 205 men and 432 women aged 18-87 years, who were randomly sampled from various districts in Ho Chi Minh City (Vietnam) according to a proportional sampling scheme. Serum concentration of 25(OH)D and PTH were measured by the Electrochemiluminescence immunoassay on the Roche Elecsys 10100/201 system (Roche Diagnosis Elecsys). Vitamin D insufficiency was quantified as serum 25(OH)D levels below 30 ng/ml (75 nmol/L).The average age for men and women was 43.8 +/- 18.4 years (mean +/- SD) and 47.7 +/- 17.1 years, respectively. The mean 25(OH)D concentration in men (36.8 +/- 10.2 ng/mL) was significantly higher than in women (30.1 +/- 5.9; P < 0.0001). The prevalence of vitamin D insufficiency in men was 20% (41/205) which was significantly lower than in women (46%, 199/432). Age, height and weight were independent predictors of 25(OH)D concentrations, and the three factors explained 15% and 5% of variance in 25(OH)D in men and women, respectively. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued.These data show that vitamin D insufficiency is common even in tropical region, and that women had a greater risk of vitamin D insufficiency than men. These data suggest that an elevation in PTH cannot be used as a marker for vitamin D deficiency.