Evaluation of gut motility in type II diabetes by the radiopaque marker method
Evaluation of gut motility in type II diabetes by the radiopaque marker method
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DOI：
10.1046/j.1440-1746.2000.02076.x
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发表时间：
2000-04-01
影响因子：
4.1
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Iida, M;Ikeda, M;Hori, M
背景：通过对21例无任何神经病变症状的2型糖尿病患者的检查，评价不透射线标记物方法检测糖尿病胃肠动力障碍的临床应用价值。方法：使用Sitzmark胶囊(R)后，用腹部平片定位标记物，用Arhan方法计算标记物通过7个消化道区域的时间。测定给药后45min的对乙酰氨基酚血药浓度，以评估胃排空时间。结果：糖尿病患者上消化道平均通过时间(+/-SD)较对照组略有延长(14.4+/-8.3对9.9+/-6.1 h)，但差异无统计学意义。与对照组(23.3±8.5和33.2±11.0)h相比，下消化道和全肠道的转运时间显著延长(分别为44.6±20.9和57.9±22.3h)。这些标志物从胃到小肠的转运时间与对乙酰氨基酚的血药浓度高度相关(r=0.693)。通过全结肠的时间(r=0.564)和通过全肠道的时间(r=0.630)与CVR-R高度相关。结论：X线不透明标记法是检测胃肠动力障碍的有用工具。在没有神经病变症状的II型糖尿病患者中，下消化道可能在上消化道受损之前恶化。(C)2000年Blackwell Science Asia Pty Ltd.
Background: The clinical usefulness of the radiopaque marker method for detecting diabetic gastrointestinal motility disturbances, was evaluated by examining 21 type II diabetes subjects who did not have any neuropathic symptoms.Methods: After administration of a Sitzmark capsule (R), markers were located using plain abdominal radiographs, and the transit time of the markers through seven areas of digestive tract was calculated by Arhan's methods. The plasma concentration of acetaminophen at 45 min after oral administration was measured to evaluate gastric emptying time. The coefficient of variation of R-R intervals on the electrocardiograms (CVR-R) was measured to evaluate parasympathetic autonomic function.Results: In the diabetics, the average (+/- SD) transit time through upper digestive tracts was slightly but not significantly elongated compared with control subjects (14.4 +/- 8.3 vs 9.9 +/- 6.1 h). Significant elongation was observed in transit time through the lower digestive tracts or the whole gut (44.6 +/- 20.9 and 57.9 +/- 22.3 h, respectively) compared with control subjects (23.3 +/- 8.5 and 33.2 +/- 11.0 h). The transit time of the markers from stomach to small intestine was highly correlated (r = 0.693) with plasma concentration of acetaminophen. The transit time through either the whole colon (r = 0.564) or the whole gut (r = 0.630) was highly correlated with CVR-R.Conclusions: These findings suggest that the radiopaque marker method is a useful tool for detecting the sections of the digestive tract responsible for gut motility disturbances. In type II diabetics with no neuropathic symptoms, the lower digestive tracts may deteriorate prior to the impairment of upper digestive tracts. (C) 2000 Blackwell Science Asia Pty Ltd.