Autophagy and the Immune Response
Autophagy and the Immune Response
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DOI：
10.1007/978-981-15-0602-4_27
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Hu, Zhuowei
中科院分区：
文献类型：
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作者：
Cui, Bing;Lin, Heng;Hu, Zhuowei
先天免疫和适应性免疫在维持机体正常生理功能和疾病发生发展中起着至关重要的作用。在先天免疫应答中，异质自噬可以直接清除细胞内病原体，同时激活包括tlr和nlr在内的PRRs，触发其信号转导通路，促进NKT细胞活化、细胞因子分泌和吞噬。在适应性免疫应答中，自噬反应对T淋巴细胞的稳态、功能和分化、B淋巴细胞的存活和发育以及浆细胞的存活具有重要影响。本文综述了自噬在先天免疫系统和获得性免疫系统中的重要作用。进一步阐明自噬调节免疫系统的机制对于阐明各种疾病的确切机制和开发新的治疗方法至关重要。
Innate immunity and adaptive immunity play critical roles in maintaining normal physiological functions and the development of diseases. In innate immune responses, heterogeneous autophagy can directly remove intracellular pathogens while activating PRRs, including TLRs and NLRs, to trigger their signal transduction pathways and promote NKT cell activation, cytokine secretion, and phagocytosis. In adaptive immune responses, the autophagy reaction has an important effect on the homeostasis, function, and differentiation of T lymphocytes, the survival, and development of B lymphocytes and the survival of plasma cells. This review highlights the key role that autophagy plays in the innate immune system and the acquired immune system. Further clarifying the mechanism by which autophagy regulates the immune system is essential for elucidating the precise mechanisms of various diseases and for developing new treatment methods.