Long-Lasting Measles Outbreak Affecting Several Unrelated Networks of Unvaccinated Persons
Long-Lasting Measles Outbreak Affecting Several Unrelated Networks of Unvaccinated Persons
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DOI：
10.1086/644783
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发表时间：
2009-11-15
影响因子：
6.4
通讯作者：
Tipples, Graham
中科院分区：
文献类型：
--
作者：
Dallaire, Frederic;De Serres, Gaston;Tipples, Graham
尽管人口免疫力水平估计接近 95%，加拿大魁北克省还是爆发了麻疹疫情，造成 94 例病例。与之前大多数未接种疫苗的儿童属于单一社区的疫情不同，这次疫情的病例来自分散在人口中的几个不相关的未接种疫苗者网络。大约三分之一的实验室确诊病例没有发现流行病学联系。这次疫情表明，未接种疫苗的个体聚集水平的微小变化就可能导致高度接种疫苗的人群持续传播。需要对可能危及消除的未接种疫苗个体的聚集水平进行数学工作。
Despite a population immunity level estimated at similar to 95%, an outbreak of measles responsible for 94 cases occurred in Quebec, Canada. Unlike previous outbreaks in which most unvaccinated children belonged to a single community, this outbreak had cases coming from several unrelated networks of unvaccinated persons dispersed in the population. No epidemiological link was found for about one-third of laboratory-confirmed cases. This outbreak demonstrated that minimal changes in the level of aggregation of unvaccinated individuals can lead to sustained transmission in highly vaccinated populations. Mathematical work is needed regarding the level of aggregation of unvaccinated individuals that would jeopardize elimination.