Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network.
Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network.
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成纤维细胞生长因子 21：一种新兴的脂质代谢和代谢网络的多效调节剂。
DOI：
10.1016/j.gendis.2023.06.033
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发表时间：
2024-05
期刊：
影响因子：
6.8
通讯作者：
You, Jinming
中科院分区：
文献类型：
--
作者：
Li, Shuo;Zou, Tiande;Chen, Jun;Li, Jiaming;You, Jinming
成纤维细胞生长因子21（Fibroblast growth factor 21，FGF 21）最初被认为是一种重要的代谢调节因子，在通过代谢网络调节多种代谢参数方面发挥着重要的生理作用。作为一种新型的多功能内分泌生长因子，FGF 21在代谢网络中的作用值得广泛探索。这一见解是从以下观察中获得的：调节脂质代谢、糖原转化和生物学有效性的FGF 21依赖性机制通过肝脏、脂肪组织、中枢神经系统和交感神经的协调参与而发生。本文综述了FGF 21-解偶联蛋白1（UCP 1）信号在脂质代谢中的作用以及FGF 21如何加重非酒精性脂肪性肝病（NAFLD）。此外，这篇综述揭示了FGF 21调控糖脂代谢的机制。最近关于FGF 21在代谢网络中的作用的研究主要集中在糖脂代谢的关键途径上。FGF 21已被证明在代谢网络中具有多种调节作用。由于目前对FGF 21在代谢网络中的具体调控途径还没有足够的了解，本文就FGF 21的代谢机制进行了综述，探讨了FGF 21如何与不同的组织和器官发生作用，并为进一步深入研究FGF 21靶向治疗代谢性疾病奠定了理论基础。
Fibroblast growth factor 21 (FGF21) was originally identified as an important metabolic regulator which plays a crucial physiological role in regulating a variety of metabolic parameters through the metabolic network. As a novel multifunctional endocrine growth factor, the role of FGF21 in the metabolic network warrants extensive exploration. This insight was obtained from the observation that the FGF21-dependent mechanism that regulates lipid metabolism, glycogen transformation, and biological effectiveness occurs through the coordinated participation of the liver, adipose tissue, central nervous system, and sympathetic nerves. This review focuses on the role of FGF21-uncoupling protein 1 (UCP1) signaling in lipid metabolism and how FGF21 alleviates non-alcoholic fatty liver disease (NAFLD). Additionally, this review reveals the mechanism by which FGF21 governs glucolipid metabolism. Recent research on the role of FGF21 in the metabolic network has mostly focused on the crucial pathway of glucolipid metabolism. FGF21 has been shown to have multiple regulatory roles in the metabolic network. Since an adequate understanding of the concrete regulatory pathways of FGF21 in the metabolic network has not been attained, this review sheds new light on the metabolic mechanisms of FGF21, explores how FGF21 engages different tissues and organs, and lays a theoretical foundation for future in-depth research on FGF21-targeted treatment of metabolic diseases.
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影响因子：
8.1
作者：
Singhal G;Kumar G;Chan S;Fisher FM;Ma Y;Vardeh HG;Nasser IA;Flier JS;Maratos-Flier E
通讯作者：
Maratos-Flier E
DOI：
10.1124/jpet.121.000514
发表时间：
2021-08
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
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通讯作者：
Liu W
影响因子：
4
作者：
Chen, Michelle M.;Hale, Clarence;Veniant, Murielle M.
通讯作者：
Veniant, Murielle M.
影响因子：
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作者：
Asrih, Mohamed;Veyrat-Durebex, Christelle;Jornayvaz, Francois R.
通讯作者：
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