Recent Advances in Detection, Isolation, and Imaging Techniques for Sulfane Sulfur-Containing Biomolecules.
Recent Advances in Detection, Isolation, and Imaging Techniques for Sulfane Sulfur-Containing Biomolecules.
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DOI：
10.3390/biom11111553
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发表时间：
2021-10-20
期刊：
影响因子：
5.5
通讯作者：
Hanaoka K
中科院分区：
文献类型：
--
作者：
Echizen H;Sasaki E;Hanaoka K
硫化氢及其氧化产物参与许多生物过程，而硫烷硫化合物（硫原子与其他硫原子键合），如氢过硫化物（R-S-SH）、多硫化物（R-S-Sn-S-R）、多硫化氢（H2Sn）等，引起了越来越多的兴趣。为了表征它们的生理和病理生理作用，需要选择性检测技术。传统上，硫烷硫化合物可以通过氰解来检测，涉及氰化物离子的亲核攻击以裂解硫-硫键。生成的硫氰酸盐与铁离子反应，生成的硫氰酸铁络合物可以通过吸收光谱很容易地检测到。最近对硫烷硫化合物作为亲核试剂和亲电试剂性质的探索导致了用于生物样品中硫烷硫化合物的检测、分离和生物成像的各种化学技术的发展。其中包括标签开关技术、LC-MS/MS、拉曼光谱和荧光探针。在此，我们概述了可用于在生物环境中特异性检测硫烷硫物种的技术。
Hydrogen sulfide and its oxidation products are involved in many biological processes, and sulfane sulfur compounds, which contain sulfur atoms bonded to other sulfur atom(s), as found in hydropersulfides (R-S-SH), polysulfides (R-S-Sn-S-R), hydrogen polysulfides (H2Sn), etc., have attracted increasing interest. To characterize their physiological and pathophysiological roles, selective detection techniques are required. Classically, sulfane sulfur compounds can be detected by cyanolysis, involving nucleophilic attack by cyanide ion to cleave the sulfur–sulfur bonds. The generated thiocyanate reacts with ferric ion, and the resulting ferric thiocyanate complex can be easily detected by absorption spectroscopy. Recent exploration of the properties of sulfane sulfur compounds as both nucleophiles and electrophiles has led to the development of various chemical techniques for detection, isolation, and bioimaging of sulfane sulfur compounds in biological samples. These include tag-switch techniques, LC-MS/MS, Raman spectroscopy, and fluorescent probes. Herein, we present an overview of the techniques available for specific detection of sulfane sulfur species in biological contexts.
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影响因子：
11.4
作者：
Honda K;Hishiki T;Yamamoto S;Yamamoto T;Miura N;Kubo A;Itoh M;Chen WY;Takano M;Yoshikawa T;Kasamatsu T;Sonoda S;Yoshizawa H;Nakamura S;Itai Y;Shiota M;Koike D;Naya M;Hayakawa N;Naito Y;Matsuura T;Iwaisako K;Masui T;Uemoto S;Nagashima K;Hashimoto Y;Sakuma T;Matsubara O;Huang W;Ida T;Akaike T;Masugi Y;Sakamoto M;Kato T;Ino Y;Yoshida H;Tsuda H;Hiraoka N;Kabe Y;Suematsu M
通讯作者：
Suematsu M
影响因子：
4.6
作者：
Miyamoto R;Koike S;Takano Y;Shibuya N;Kimura Y;Hanaoka K;Urano Y;Ogasawara Y;Kimura H
通讯作者：
Kimura H
影响因子：
4.6
作者：
Kimura Y;Toyofuku Y;Koike S;Shibuya N;Nagahara N;Lefer D;Ogasawara Y;Kimura H
通讯作者：
Kimura H
影响因子：
16.6
作者：
Matsuno S;Yamashina M;Sei Y;Akita M;Kuzume A;Yamamoto K;Yoshizawa M
通讯作者：
Yoshizawa M
DOI：
10.1002/anie.201506887
发表时间：
2015-11-16
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Chen W;Rosser EW;Matsunaga T;Pacheco A;Akaike T;Xian M
通讯作者：
Xian M