The background of reduced face specificity of N170 in congenital prosopagnosia.
The background of reduced face specificity of N170 in congenital prosopagnosia.
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DOI：
10.1371/journal.pone.0101393
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kovács G
中科院分区：
文献类型：
--
作者：
Németh K;Zimmer M;Schweinberger SR;Vakli P;Kovács G
先天性面容失认症是一种终身性的面孔识别障碍，缺乏结构性脑损伤的证据。为了研究先天性面容失认症的神经相关性，我们测量了同一家庭的三名成员（父亲（56岁），儿子（25岁）和女儿（22岁））和年龄匹配的神经典型参与者（年轻对照组：n = 14; 24.5 y±2.1;老年对照组：n = 6; 57.3 y±5.4）的事件相关电位的面孔敏感N170成分。 为了比较先天性面容失认症和神经型参与者的N170面部敏感性，我们测量了面部和相位扰乱随机噪声刺激的事件相关电位。在神经型，我们发现显着更大的N170振幅的面孔相比，噪音刺激，反映正常的早期面部处理。相比之下，先天性面容失认症的参与者表现出N170的面部敏感性降低，这是由于比正常噪音引起的N170更大，而不是更小的面部引起的N170。有趣的是，单次试验分析显示，先天性面容失认症患者的面部敏感性缺乏与θ频段（4-7 Hz，130-190 ms）中较大的振荡功率和锁相以及噪声刺激反应延迟的较低试验间抖动有关。总之，这些结果表明，先天性面容失认症是由于赤字的早期，结构编码步骤的面孔知觉之间的过滤和非面孔刺激。
Congenital prosopagnosia is lifelong face-recognition impairment in the absence of evidence for structural brain damage. To study the neural correlates of congenital prosopagnosia, we measured the face-sensitive N170 component of the event-related potential in three members of the same family (father (56 y), son (25 y) and daughter (22 y)) and in age-matched neurotypical participants (young controls: n = 14; 24.5 y±2.1; old controls: n = 6; 57.3 y±5.4). To compare the face sensitivity of N170 in congenital prosopagnosic and neurotypical participants we measured the event-related potentials for faces and phase-scrambled random noise stimuli. In neurotypicals we found significantly larger N170 amplitude for faces compared to noise stimuli, reflecting normal early face processing. The congenital prosopagnosic participants, by contrast, showed reduced face sensitivity of the N170, and this was due to a larger than normal noise-elicited N170, rather than to a smaller face-elicited N170. Interestingly, single-trial analysis revealed that the lack of face sensitivity in congenital prosopagnosia is related to a larger oscillatory power and phase-locking in the theta frequency-band (4–7 Hz, 130–190 ms) as well as to a lower intertrial jitter of the response latency for the noise stimuli. Altogether, these results suggest that congenital prosopagnosia is due to the deficit of early, structural encoding steps of face perception in filtering between face and non-face stimuli.
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