Thyroxine turnover in euthyroid man with special reference to changes with age.
Thyroxine turnover in euthyroid man with special reference to changes with age.
复制标题
甲状腺功能正常的男性的甲状腺素周转率，特别是随年龄的变化。
DOI：
10.1172/jci104664
复制
发表时间：
1962
期刊：
影响因子：
--
通讯作者：
S. E. Crowder
中科院分区：
文献类型：
--
作者：
R. I. Gregerman;G. W. Gaffney;N. Shock;S. E. Crowder
多年来，甲状腺被认为与伴随年龄增长的基础代谢率下降有关。虽然最近的证据表明，氧气消耗的变化可能只是反映了“代谢质量”的减少（1），放射性同位素技术和方法的出现，测量血液中的甲状腺激素水平导致了希望，新的信息轴承甲状腺的作用可能成为可用。我们回顾了其他人的研究，并在以前的出版物中介绍了我们自己的结果，这些出版物涉及甲状腺功能正常的男性中年龄与血清蛋白结合碘（PBI）和甲状腺放射性碘蓄积的关系（2，3）。这些数据表明，PBI没有变化，但放射性碘积累和甲状腺血浆放射性碘清除率随年龄的增长而下降。不幸的是，放射性碘数据很难解释，因为不可能将示踪剂放射性碘摄取的减少与甲状腺激素形成的减少等同起来（3）。此外，尽管摄取的年龄依赖性降低的统计学显著性是明确的，但是个体值的分散使得只能近似变化的幅度。虽然在临床上用于研究甲状腺功能的极端情况，但很少有证据表明，在甲状腺功能正常的男性中，基础代谢率、血清PBI或甲状腺对放射性碘的摄取与甲状腺激素的产生率密切相关。因此，现有的研究都没有特别阐明甲状腺活性是否随年龄变化的问题。大约十年前，Riggs回顾了定量估计甲状腺激素形成率的方法，但这些方法尚未用于年龄与甲状腺激素形成率之间关系的研究。
For many years the thyroid was thought to be involved in the decrease of basal metabolic rate that accompanies advancing age. Although recent evidence suggests that the change in oxygen consumption may merely reflect a decrease in "metabolic mass" (1), the advent of radioisotope techniques and methods for measuring the level of thyroid hormone in blood led to the hope that new information bearing on the role of the thyroid might become available. We have reviewed the investigations of others and presented our own results in previous publications dealing with the relationship of age to serum protein-bound iodine (PBI) and the thyroidal accumulation of radioiodide in euthyroid man (2, 3). The data suggest that the PBI does not change, but that radioiodide accumulation and thyroidal plasma radioiodide clearance decrease with age. Unfortunately, the radioiodide data are difficult to interpret, since it is not possible to equate a decrease in the uptake of tracer radioiodide with a decrease in thyroid hormone formation (3). Moreover, although the statistical significance of the age-dependent decrease in uptake is clear, the scatter of the individual values is such that the magnitude of the change can be only approximated. Although clinically useful for studying the extremes of thyroid function, there is little evidence that the basal metabolic rate, the serum PBI, or the thyroidal uptake of radioiodide is closely related to the rate of thyroid hormone production in euthyroid man. None of the available studies, therefore, particularly clarifies the issue of whether thyroid activity changes with age. About ten years ago Riggs reviewed the methods available for estimating quantitatively the rate of thyroid hormone formation, but these have not been used in studies of the relationship of age to