Determination of the Kinetic Parameters for 123I Uptake by the Thyroid, Thyroid Weights, and Thyroid Volumes in Present-day Healthy Japanese Volunteers
Determination of the Kinetic Parameters for 123I Uptake by the Thyroid, Thyroid Weights, and Thyroid Volumes in Present-day Healthy Japanese Volunteers
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DOI：
10.1097/hp.0000000000001144
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发表时间：
2020-04-01
期刊：
影响因子：
2.2
通讯作者：
Kusuhara, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kudo, Takashi;Inano, Akihiro;Kusuhara, Hiroyuki
本研究的目的是评估决定给药后 24 小时内甲状腺中放射性碘化物摄取率的动力学参数，并估计当今日本人的甲状腺体积/质量。方法：我们测定了日本健康男性口服 I-123（4.5-8.0 MBq）后甲状腺对 I-123 的摄取率（不限碘）。 2012 年至 2016 年，在对 7,651 名男性和 3,331 名女性受试者进行尸检时收集了大量甲状腺。通过超声检查和磁共振成像对 52 名男性受试者的甲状腺体积进行了评估。结果：24小时甲状腺对I-123的摄取率为16.1+/-5.4%。进行动力学模型分析以获得I-123的甲状腺摄取和尿排泄的清除率(L h(-1))(分别为0.499+/-0.258和2.10+/-0.39L h(-1))。 19-52 岁男性和女性受试者的甲状腺质量平均分别为 19.8 克（95% 置信区间为 18.3-19.5 克）和 15.5 克（95% 置信区间为 14.7-16.2 克）。通过超声检查和磁共振成像估计的甲状腺体积分别为 17.5 +/- 5.2 和 14.2 +/- 5.3 mL。在健康的日本人中，甲状腺在 24 小时内摄取放射性碘或其动力学参数在至少 50 年内没有发生显着变化。这些日本特有的动力学参数将允许定量估计福岛事故造成的辐射暴露及其在个人撤离或留在福岛期间的变化。
The purpose of this study was to evaluate the kinetic parameters that determine the uptake rate of radioiodide in the thyroid over 24 h after administration and to estimate thyroid volumes/masses of present-day Japanese. Methods: We determined the thyroid uptake rate of I-123 in healthy male Japanese after oral administration (4.5-8.0 MBq) without iodine restriction. Masses of thyroid glands were collected in 2012-2016 during autopsies of 7,651 male and 3,331 female subjects. Volumes of thyroid glands were estimated by ultrasonography and magnetic resonance imaging in 52 male subjects. Results: The thyroid uptake rate of I-123 for 24 h was 16.1 +/- 5.4%. Kinetic model analysis was conducted to obtain the clearances (L h(-1)) for thyroid uptake and urinary excretion of I-123 (0.499 +/- 0.258 and 2.10 +/- 0.39 L h(-1), respectively). The masses of thyroid glands were on average 19.8 g (95% confidence interval of 18.3-19.5 g) and 15.5 g (95% confidence interval of 14.7-16.2 g) in male and female subjects aged 19-52 y, respectively. Volumes of thyroid glands estimated by ultrasonography and magnetic resonance imaging were 17.5 +/- 5.2 and 14.2 +/- 5.3 mL, respectively. In healthy Japanese, there has been no significant change for at least 50 y in the thyroid uptake of radioiodide over 24 h or in its kinetic parameters. These Japanese-specific kinetic parameters will allow quantitative estimation of the radiation exposure from the Fukushima accident and its variance during the individual's evacuation from or stay in Fukushima.