FLUOSOL AND HYPERBARIC-OXYGEN AS AN ADJUNCT TO RADIATION-THERAPY IN THE TREATMENT OF MALIGNANT GLIOMAS - A PILOT-STUDY
FLUOSOL AND HYPERBARIC-OXYGEN AS AN ADJUNCT TO RADIATION-THERAPY IN THE TREATMENT OF MALIGNANT GLIOMAS - A PILOT-STUDY
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DOI：
10.3109/10731199209119738
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发表时间：
1992-01-01
期刊：
影响因子：
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通讯作者：
ROCKWELL, S
中科院分区：
文献类型：
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作者：
DOWLING, S;FISCHER, JJ;ROCKWELL, S
据报道，一些临床试验使用氟雾剂和氧气呼吸作为放射治疗的辅助手段。然而，理论考虑和动物实验表明，与全氟化学品和常压氧或单独使用高压氧相比，全氟化学品和高压氧的组合在更大程度上增加了肿瘤的氧合作用和辐射反应。这是关于在人类中使用氟雾剂和高压氧与辐射的初步研究的第一份报告。20例间变性星形细胞瘤或多形性胶质母细胞瘤患者在一项I期试验中接受了氟索和HBO三大气压放射治疗。氟醇总剂量从6个疗程的42 ml/kg增加到4个疗程的80 ml/kg。患者在氟唑给药后，在HBO室以每周600 cGy的分数照射。16例患者完成治疗；没有必要中断治疗毒性。氟唑醇/HBO的加入并未增加HBO相关毒性的发生率。未见明显的慢性毒性。这项初步研究表明，氟索和高压氧可以安全地用作治疗人类肿瘤的放射辅助手段。
Several clinical trials have been reported using Fluosol and oxygen breathing as an adjunct to radiation. Theoretical considerations and animal experiments, however, indicate that a combination of perfluorochemicals and hyperbaric oxygen (HBO) increases tumor oxygenation and radiation response to a greater extent than is seen either with a perfluorochemical and normobaric oxygen or with HBO alone. This is the first report of a pilot study of the use of Fluosol and HBO with radiation in humans. Twenty patients with anaplastic astrocytoma or glioblastoma multiforme were treated in a phase I trial of radiation with Fluosol and HBO at three atmospheres. Total Fluosol dose was escalated from 42 ml/kg in six courses to 80 ml/kg in four courses. Patients were irradiated in an HBO chamber with 600 cGy weekly fractions following Fluosol administration. Sixteen patients completed treatment; no interruption was necessitated by treatment toxicity. The addition of Fluosol/HBO did not increase the incidence of HBO related toxicities. No significant chronic toxicities were seen. This pilot study demonstrates that Fluosol and HBO can safely be used as an adjunct to radiation in the treatment of human tumors.