Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats.
Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats.
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DOI：
10.1016/s0014-2999(02)02472-x
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发表时间：
2002-11
影响因子：
5
通讯作者：
J. Rudd;Kouichi Yamamoto;A. Yamatodani;N. Takeda
中科院分区：
文献类型：
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作者：
J. Rudd;Kouichi Yamamoto;A. Yamatodani;N. Takeda
在大鼠中研究了顺铂诱导高岭土摄入（异食癖）的急性（0-24 h）和延迟（24-48和48-72 h）阶段的能力。顺铂3 mg/kg，腹腔注射，在0-24小时（P<0.001）和48-72小时（P<0.05）期间诱导高岭土消耗，地塞米松1 mg/kg，i. p.，每12小时单独或与昂丹司琼2 mg/kg联合给药，腹膜内，每12 h给药一次（P<0.05）。作为单次治疗，恩丹西酮2 mg/kg，i. p.，每12小时给药一次可使顺铂诱导的高岭土消耗在0-24小时期间增加41%（P<0.05），但对延迟反应没有改善作用（P>0.05）。地塞米松1 mg/kg，腹腔注射，每12小时给药一次，顺铂3和6 mg/kg，腹膜内，而不是昂丹司琼2 mg/kg，i. p.，每12小时给药一次（P>0.05）可减少食物消耗并降低大鼠体重。顺铂的最高剂量为6 mg/kg，腹膜内，诱发急性（P<0.001），但不延迟高岭土摄入（P>0.05）。顺铂诱导急性和迟发性异食癖的作用是复杂的，可能受到改变食欲的药物的影响。
The ability of cisplatin to induce acute (0–24 h) and delayed (24–48 and 48–72 h) phases of kaolin ingestion (pica) was investigated in the rat. Cisplatin 3 mg/kg, i.p., induced kaolin consumption during the 0–24- (P<0.001) and 48–72-h (P<0.05) periods that was antagonised by dexamethasone 1 mg/kg, i.p., administered every 12 h alone or in combination with ondansetron 2 mg/kg, i.p., administered every 12 h (P<0.05). As a single treatment, ondansetron 2 mg/kg, i.p., administered every 12 h potentiated cisplatin-induced kaolin consumption by 41% (P<0.05) during the 0–24-h period but had no action to modify the delayed response (P>0.05). Dexamethasone 1 mg/kg, i.p., administered every 12 h and cisplatin 3 and 6 mg/kg, i.p., but not ondansetron 2 mg/kg, i.p., administered every 12 h (P>0.05) reduced food consumption and decreased rat weight. The highest dose of cisplatin 6 mg/kg, i.p., induced acute (P<0.001) but not delayed kaolin ingestion (P>0.05). The action of cisplatin to induce acute and delayed pica is complicated and may be affected by drugs that modify appetite.