Use of a Cesium Primary Beam for Liquid SIMS Analysis of Bio-Organic Compounds
Use of a Cesium Primary Beam for Liquid SIMS Analysis of Bio-Organic Compounds
复制标题
使用铯主束对生物有机化合物进行液体 SIMS 分析
DOI：
10.1007/978-3-642-87148-1_19
复制
发表时间：
1983
影响因子：
2.1
通讯作者：
A. Burlingame
中科院分区：
文献类型：
--
作者：
W. Aberth;A. Burlingame
1976 年，BENNINGHOVEN、JASPERS 和 SICHTERMAN 首次报道了使用氩主束轰击覆盖有大约单层样品的金属靶，从许多氨基酸中获得二次离子质谱 [1]。在他们的开创性工作中，他们证明了可以从非挥发性和热不稳定的复杂有机分子中获得重要的分子和结构信息，并且标记分子 SIMS 技术目前正在广泛使用。然而，分子 SIMS 产生固有的短持续时间的小二次离子信号，使得该技术通常无法被传输效率相对较低的高分辨率串联型质谱仪使用。
In 1976 BENNINGHOVEN, JASPERS and SICHTERMAN first reported on obtaining secondary ion mass spectra from a number of amino acids using an argon primary beam to bombard a metal target covered with approximately a monolayer of sample [1]. In their pioneering work, they demonstrated that important molecular and structural information can be obtained from complex organic molecules which are nonvolatile and thermally labile, and the technique, labeled molecular SIMS, is in current and widespread use. Molecular SIMS, however, yields an inherently small secondary ion signal of short duration making the technique generally inaccessible to high resolution tandem type mass spectrometers of relatively low transmission efficiency.