Heating of the Eye by a Retinal Prosthesis: Modeling, Cadaver and In Vivo Study
Heating of the Eye by a Retinal Prosthesis: Modeling, Cadaver and In Vivo Study
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DOI：
10.1109/tbme.2011.2171961
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发表时间：
2012-02-01
影响因子：
4.6
通讯作者：
Grayden, David B.
中科院分区：
文献类型：
--
作者：
Opie, Nicholas L.;Burkitt, Anthony N.;Grayden, David B.
为了开发具有大量电极的视网膜植入物，必须确保它们不会因电路产生的热量而对神经组织造成损害。了解引起热损伤的功率量将有助于开发植入物的功率预算，这对假体电路的设计有重要影响。在本研究中，我们测量了视网膜上多个位置的温度，同时在尸体和体内使用各种假体植入位置加热视网膜。还创建了猫眼的有限元热模型，并通过尸体和体内试验进行了验证，从而无需额外的动物实验就可以评估更大范围的热影响。为了确保视网膜组织温度升高不超过2摄氏度，一个5毫米× 5毫米的脉黄膜上植入的加热元件的耗电量不得超过135兆瓦（5.4兆瓦/毫米）。
In order to develop retinal implants with a large number of electrodes, it is necessary to ensure that they do not cause damage to the neural tissue by the heat that the electrical circuits generate. Knowledge of the amount of power that induces thermal damage will assist in development of power budgets for implants, which has a significant effect upon the design of the prostheses circuitry. In this study, temperatures were measured at multiple locations on the retina while the retina was heated in cadaver and in vivo preparations using a variety of prosthesis implantation sites. A finite element thermal model of the cat eye was also created and validated by the cadaver and in vivo tests, allowing for a much larger spectrum of thermal influences to be evaluated without additional animal experimentation. To ensure that retinal tissue temperatures are not increased by more than 2 degrees C, a 5 mm x 5 mm, suprachoroidally implanted heating element must not dissipate more than 135 mW (5.4 mW/mm(2)).