Cardiovascular effects of fine particulate matter components in highway patrol officers
Cardiovascular effects of fine particulate matter components in highway patrol officers
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DOI：
10.1080/08958370701495238
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Riediker, Michael
中科院分区：
文献类型：
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作者：
Riediker, Michael
暴露于交通中的细颗粒物（PM2.5）会影响心率变异性、血栓形成和炎症。这项再分析调查了可能导致非吸烟健康男性北卡罗来纳州公路巡逻队的这种影响的成分。九名警官在晚班期间接受了四次研究。在巡逻汽车内测量PM2.5、其元素组成和气态共污染物。与PM2.5相关的组分分别与每次轮班后10和15小时测量的心脏和血液参数进行比较。使用了PM2.5控制的混合效应模型。与健康终点独立于PM2.5的成分是钙（尿酸和血管性血友病因子[vWF]升高，蛋白C降低），铬（白色血细胞计数和白细胞介素6增加），醛类（vWF、正常R-R间期的平均周期长度[MCL]和心率变异性参数pNN 50增加），铜（血尿素氮和MCL增加;纤溶酶原激活物抑制物1减少）和硫（室性异位搏动增加）。控制气体共污染物的效果估计影响不大。观察到的变化是一致的，从变速交通（特征为铜，硫和醛）和土壤（钙）的PM2.5的影响。铬与炎症标志物的关联在交通颗粒之前没有发现，但它们与毒理学文献一致，尽管浓度较低。铜，硫，醛，钙，铬或含有这些元素的化合物似乎直接有助于炎症，凝血和心脏对PM2.5的反应，从交通在调查的巡逻队。
Exposure to fine particulate matter (PM2.5) from traffic affects heart-rate variability, thrombosis, and inflammation. This reanalysis investigated components potentially contributing to such effects in nonsmoking healthy male North Carolina highway patrol troopers. Nine officers were studied four times during their late shift. PM2.5, its elemental composition, and gaseous copollutants were measured inside patrol cars. Components correlated to PM2.5 were compared to cardiac and blood parameters measured 10 and 15 h, respectively, after each shift. Mixed effects models with control for PM2.5 were used. Components that were associated with health endpoints independently from PM2.5 were calcium (increased uric acid and von Willebrand Factor [vWF], decreased protein C), chromium (increased white blood cell count and interleukin 6), aldehydes (increased vWF, mean cycle length of normal R-R intervals [MCL], and heart-rate variability parameter pNN50), copper (increased blood urea nitrogen and MCL; decreased plasminogen activator inhibitor 1), and sulfur (increased ventricular ectopic beats). Control for gaseous copollutants had little effect on the effect estimates. The changes observed are consistent with effects reported earlier for PM2.5 from speed-change traffic (characterized by copper, sulfur, and aldehydes) and from soil (with calcium). The associations of chromium with inflammation markers were not seen before for traffic particles, but they are consistent with the toxicological literature although at low concentrations. Copper, sulfur, aldehydes, calcium, and chromium or compounds containing these elements seem to directly contribute to the inflammatory, coagulatory, and cardiac response to PM2.5 from traffic in the investigated patrol troopers.