The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape:: an in-vitro study
The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape:: an in-vitro study
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DOI：
10.1016/j.jhin.2007.10.009
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发表时间：
2008-01-01
影响因子：
6.9
通讯作者：
Todorov, S. D.
中科院分区：
文献类型：
--
作者：
Mehtar, S.;Wiid, I.;Todorov, S. D.
对耐甲氧西林金黄色葡萄球菌（MRSA）、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、白色念珠菌和结核分枝杆菌（MTB）的临床分离株进行了铜（Cu）及其合金的抗菌试验。不锈钢和聚氯乙烯（PVC）用作对照。测定了在室温（24 ℃）和4 ℃下抑制试验分离株所需的Cu量。在室温下，Cu、DZR黄铜（Cu62%，Pb2.5%，砷酸盐0.13%，Zn22.5%）和黄铜70/30（Cu70%，Zn30%）对C. albicans和K. pneumoniae 60 min; albicans 60 min，K.铜绿假单胞菌在180 min时被黄铜70/30和镍银（NiAg）抑制，在270 min时被Cu和DZR抑制。Cu和DZR抑制A.白色，其他合金在360分钟时有效。不锈钢和PVC显示很少或没有抑制活性。两米结核菌株，一个异烟肼耐药（R267）和其他多药耐药（R432），表现出与PVC相比，铜的生长抑制分别为98%和88%;其他合金活性较低。R267的阳性时间（TTP）对于Cu> 15天，对于其他合金为11天;对于R432为5天。当铜含量> 55%时，铜及其合金对医院内病原菌和结核分枝杆菌的抑制效果最好。(c)2007年，医院感染协会。由爱思唯尔有限公司出版。保留所有权利。
Clinical isolates of meticillin- resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans and Mycobacterium tuberculosis (MTB) were tested against copper (Cu) and its alloys. Stainless steel and polyvinylchloride (PVC) were used as controls. The amount of Cu required to inhibit test isolates at room temperature (24 degrees C) and at 4 degrees C was determined. At room temperature, Cu, DZR Brass (Cu 62%, Pb 2.5%, arsenate 0.13% and Zn 22.5%) and Brass 70/30 (Cu 70% and zinc 30%) inhibited C. albicans and K. pneumoniae at 60 min; nickel si[ver (NiAg) inhibited C. albicans at 60 min and K. pneumoniae at 270 min. P. aeruginosa was inhibited by Brass 70/30 and nickel silver (NiAg) at 180 min and at 270 min by Cu and DZR. Cu and DZR inhibited A. baumannii at 180 min white the other alloys were effective at 360 min. Stainless steel and PVC showed little or no inhibitory activity. Two M. tuberculosis strains, one isoniazid resistant (R267) and the other multidrug resistant (R432), demonstrated growth inhibition with Cu of 98% and 88% respectively compared with PVC; the other alloys were less active. Time to positivity (TTP) for R267 was > 15 days with Cu and 11 days for the other alloys; with R432 it was 5 days. Effective inhibition of nosocomial pathogens and MTB by Cu and alloys was best when the Cu content was >55%. (c) 2007 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.