MODALITY-SPECIFIC RETROGRADE-AMNESIA OF FEAR
MODALITY-SPECIFIC RETROGRADE-AMNESIA OF FEAR
复制标题
DOI：
10.1126/science.1585183
复制
发表时间：
1992-05-01
期刊：
影响因子：
56.9
通讯作者：
FANSELOW, MS
中科院分区：
文献类型：
--
作者：
KIM, JJ;FANSELOW, MS
像恐惧这样的情绪反应是通过经典条件反射快速获得的。本报告探讨了获得性恐惧记忆的神经基础。通过使用令人厌恶的足部电击，大鼠被经典地条件反射以恐惧音调和上下文。在训练后1、7、14或28天在海马中进行损伤。在恐惧条件反射后1天接受损伤的大鼠中，背景恐惧被消除。然而，学习和海马病变之间的间隔较长的大鼠保留了显着的上下文恐惧记忆。在相同的动物中，病变在任何时候都不会影响对音调的恐惧反应。这些结果表明，恐惧记忆是不是一个单一的过程，海马可能有一个时间有限的作用，在联想恐惧记忆诱发的多模态（上下文），但不是单峰（音）的感官刺激。
Emotional responses such as fear are rapidly acquired through classical conditioning. This report examines the neural substrate underlying memory of acquired fear. Rats were classically conditioned to fear both tone and context through the use of aversive foot shocks. Lesions were made in the hippocampus either 1, 7, 14, or 28 days after training. Contextual fear was abolished in the rats that received lesions 1 day after fear conditioning. However, rats for which the interval between learning and hippocampal lesions was longer retained significant contextual fear memory. In the same animals, lesions did not affect fear response to the tone at any time. These results indicate that fear memory is not a single process and that the hippocampus may have a time-limited role in associative fear memories evoked by polymodal (contextual) but not unimodal (tone) sensory stimuli.