Potassium Channels and Their Potential Roles in Substance Use Disorders.
Potassium Channels and Their Potential Roles in Substance Use Disorders.
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DOI：
10.3390/ijms22031249
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发表时间：
2021-01-27
影响因子：
5.6
通讯作者：
Cadet JL
中科院分区：
文献类型：
--
作者：
McCoy MT;Jayanthi S;Cadet JL
物质使用障碍（SUD）在世界各地普遍存在。然而，要开发非常有效的药物疗法还有很多工作要做，因为重点主要集中在使用多巴胺能药物或阿片类激动剂上。在此，我们讨论了在 SUD 治疗中使用钾通道激活剂的潜力，因为已经积累的证据支持这些通道在奖励药物的作用中的作用。钾通道通过对阈值、突发放电和放电频率的影响来调节神经元动作电位。它们位于被认为对奖励药物的行为反应很重要的大脑区域。此外，它们的表达谱还受到奖励物质施用的影响。遗传学研究还表明编码钾通道的基因存在变异。重要的是，服用钾激动剂已被证明可以减少酒精摄入量并增强阿片类药物的行为效应。在甲基苯丙胺摄入量减少的动物中，钾通道表达也会增加。总之，这些结果支持了进一步投资研究的想法，这些研究重点是阐明钾通道作为 SUD 治疗干预目标的作用。
Substance use disorders (SUDs) are ubiquitous throughout the world. However, much remains to be done to develop pharmacotherapies that are very efficacious because the focus has been mostly on using dopaminergic agents or opioid agonists. Herein we discuss the potential of using potassium channel activators in SUD treatment because evidence has accumulated to support a role of these channels in the effects of rewarding drugs. Potassium channels regulate neuronal action potential via effects on threshold, burst firing, and firing frequency. They are located in brain regions identified as important for the behavioral responses to rewarding drugs. In addition, their expression profiles are influenced by administration of rewarding substances. Genetic studies have also implicated variants in genes that encode potassium channels. Importantly, administration of potassium agonists have been shown to reduce alcohol intake and to augment the behavioral effects of opioid drugs. Potassium channel expression is also increased in animals with reduced intake of methamphetamine. Together, these results support the idea of further investing in studies that focus on elucidating the role of potassium channels as targets for therapeutic interventions against SUDs.
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影响因子：
25
作者：
Cruz, HG;Ivanova, T;Lüscher, C
通讯作者：
Lüscher, C
影响因子：
3.6
作者：
Cadet, Jean Lud;Patel, Ravish;Jayanthi, Subramaniam
通讯作者：
Jayanthi, Subramaniam
DOI：
10.1111/j.1749-6632.1999.tb11298.x
发表时间：
1999-01-01
期刊：
MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS
影响因子：
--
作者：
Bond, CT;Maylie, J;Adelman, JP
通讯作者：
Adelman, JP
影响因子：
6.7
作者：
Eap, C. B.;Crettol, S.;Abriel, H.
通讯作者：
Abriel, H.
影响因子：
3.4
作者：
Cui, Jianmin
通讯作者：
Cui, Jianmin