First- and Zero-Order Kinetics of Porogen Release from the Cross-Linked Cores of Diblock Nanospheres
First- and Zero-Order Kinetics of Porogen Release from the Cross-Linked Cores of Diblock Nanospheres
复制标题
二嵌段纳米球交联核心释放致孔剂的一级和零级动力学
作者：
Guojun Liu;Jia
制备了含有腺嘌呤基团P（hcma -r- a）的聚2-氢肉桂酰氧乙基甲基丙烯酸酯（2-氢肉桂酰氧乙基甲基丙烯酸酯），并将其分离成5个组分。孔隙素和二嵌段共聚物聚{（2-肉桂酰氧乙基甲基丙烯酸酯）-随机-（2-氢肉桂酰氧乙基甲基丙烯酸酯）-随机-[2-（1-胸腺酰基乙酰氧乙基甲基丙烯酸酯）]}-嵌段聚（丙烯酸叔丁酯）P(cma -r- hcma -r- t)-b-PtBA在氯仿/环己烷中形成具有PtBA冠和P(cma -r- hcma -r- t)/P（hcma -r- a）核的胶束。胶束的核心是交联的，由于光二聚化的CEMA单元。纳米微球在氘化N，N-二甲基甲酰胺（DMF-d7）中的分散引发了孔隙素释放，并通过核磁共振波谱对其动力学进行了跟踪。低摩尔质量组分的释放近似遵循一阶速率定律，而最高摩尔质量组分的释放则为零级动力学。给出了一阶到零阶动力学转变的基本原理。同样合理的是scalin…
The porogen poly(2-hydrocinnamoyloxyethyl methacrylate) containing some adenine groups P(hCEMA-r-A) was prepared and separated into five fractions. The porogen and diblock copolymer poly{(2-cinnamoyloxyethyl methacrylate)-random-(2-hydrocinnamoyloxyethyl methacrylate)-random-[2-(1-thyminylacetoxyethyl methacrylate)]}-block-poly(tert-butyl acrylate), P(CEMA-r-hCEMA-r-T)-b-PtBA, formed micelles with PtBA coronas and P(CEMA-r-hCEMA-r-T)/P(hCEMA-r-A) cores in chloroform/cyclohexane. The cores of the micelles were cross-linked due to photodimerization of the CEMA units. Dispersion of the nanospheres in deuterated N,N-dimethylformamide (DMF-d7) triggered porogen release, and the kinetics were followed by NMR spectroscopy. While the release of the low-molar-mass fractions followed approximately the first-order rate law, zero-order kinetics was observed for the release of the fraction with the highest molar mass. The rationale for the first- to zero-order kinetic transition was given. Also justified is the scalin...