Timely antemortem and postmortem concentrations in a fatal carbamazepine overdose.
Timely antemortem and postmortem concentrations in a fatal carbamazepine overdose.
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致命卡马西平过量的及时死前和死后浓度。
DOI：
10.1520/jfs15182j
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发表时间：
2001
影响因子：
1.6
通讯作者：
R. Carlisle
中科院分区：
文献类型：
--
作者：
H. Spiller;R. Carlisle
目前还没有发表的报告，包括及时死前和死后大量过量后卡马西平浓度。我们报告一个致命的过量卡马西平与及时死前和死后卡马西平浓度。卡马西平浓度为47.7 mcg/mL，2小时前死亡和53 mcg/mL，9小时后死亡。药物浓度的轻微升高可能反映了死亡前最后2小时内药物的持续吸收。从该患者外周血管中提取的死后卡马西平浓度似乎反映了死亡时的药物浓度。
There are no published reports that include both timely antemortem and postmortem carbamazepine concentrations after massive overdose. We report a fatal overdose of carbamazepine with both timely antemortem and postmortem carbamazepine concentrations. Carbamazepine concentrations were 47.7 mcg/mL 2 h antemortem and 53 mcg/mL at 9 h postmortem. The slight rise in drug concentration may reflect continued absorption of the drug in the last 2 h before death. Postmortem carbamazepine concentrations drawn from a peripheral vessel in this patient appeared to reflect drug concentrations at the time of death.