Motor-related brain abnormalities in HIV-infected patients: a multimodal MRI study
Motor-related brain abnormalities in HIV-infected patients: a multimodal MRI study
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DOI：
10.1007/s00234-017-1912-1
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发表时间：
2017-09
期刊：
影响因子：
2.8
通讯作者：
Yawen Zhou;Ruili Li;Xiaoxiao Wang;Hui Miao;Yarui Wei;Rizwan Ali;B. Qiu;Hongjun Li
中科院分区：
文献类型：
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作者：
Yawen Zhou;Ruili Li;Xiaoxiao Wang;Hui Miao;Yarui Wei;Rizwan Ali;B. Qiu;Hongjun Li
目的人们普遍认为，HIV感染可导致HIV相关的神经认知障碍（HAND）在广泛的功能领域。一些最常见的发现是运动控制缺陷。然而，到目前为止，还没有神经影像学研究使用多模式方法评估hiv感染患者的基本运动控制。方法在本研究中，我们利用高分辨率结构成像和任务状态功能磁共振成像（fMRI）来评估hiv感染患者同质队列的大脑结构和运动功能。结果我们发现hiv感染患者的皮层区域灰质（GM）体积显著减少，这些区域涉及运动控制，包括双侧后岛皮层、运动前皮层和边缘上回。与健康对照组相比，在手部运动任务中，患者的双侧后岛皮层的激活也有所增加。更重要的是，双侧脑岛后皮质GM的减少在空间上与hiv感染患者的异常脑激活一致。此外，偏相关分析结果显示，双侧脑岛后皮质和运动前皮质的GM减少与免疫系统退化显著相关。结论本研究首次证实了hiv感染者运动表现中GM减少和异常激活在空间上是一致的。尽管尚不清楚脑缺陷是否可以恢复，但我们的研究结果可能为HAND运动功能障碍的神经损伤提供新的见解。
PurposeIt is generally believed that HIV infection could cause HIV-associated neurocognitive disorders (HAND) across a broad range of functional domains. Some of the most common findings are deficits in motor control. However, to date no neuroimaging studies have evaluated basic motor control in HIV-infected patients using a multimodal approach.MethodsIn this study, we utilized high-resolution structural imaging and task-state functional magnetic resonance imaging (fMRI) to assess brain structure and motor function in a homogeneous cohort of HIV-infected patients.ResultsWe found that HIV-infected patients had significantly reduced gray matter (GM) volume in cortical regions, which are involved in motor control, including the bilateral posterior insula cortex, premotor cortex, and supramarginal gyrus. Increased activation in bilateral posterior insula cortices was also demonstrated by patients during hand movement tasks compared with healthy controls. More importantly, the reduced GM in bilateral posterior insula cortices was spatially coincident with abnormal brain activation in HIV-infected patients. In addition, the results of partial correlation analysis indicated that GM reduction in bilateral posterior insula cortices and premotor cortices was significantly correlated with immune system deterioration.ConclusionThis study is the first to demonstrate spatially coincident GM reduction and abnormal activation during motor performance in HIV-infected patients. Although it remains unknown whether the brain deficits can be recovered, our findings may yield new insights into neurologic injury underlying motor dysfunction in HAND.