Ruthenium-Catalyzed Enantioselective Intramolecular Propargylation of Thiophenes with Propargylic Alcohols
Ruthenium-Catalyzed Enantioselective Intramolecular Propargylation of Thiophenes with Propargylic Alcohols
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DOI：
10.1021/om9001186
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发表时间：
2009-04
期刊：
影响因子：
2.8
通讯作者：
K. Kanao;Y. Miyake;Y. Nishibayashi
中科院分区：
文献类型：
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作者：
K. Kanao;Y. Miyake;Y. Nishibayashi
钌催化的带有噻吩部分的炔丙醇的对映选择性环化反应以良好到高产率提供相应的炔丙基化噻吩，具有高对映选择性（高达97%ee）。这一催化反应是通过手性联烯络合物作为关键中间体进行的。
Ruthenium-catalyzed enantioselective cyclization of propargylic alcohols bearing a thiophene moiety affords the corresponding propargylated thiophenes in good to high yields with a high enantioselectivity (up to 97% ee). This catalytic reaction is proposed to proceed via chiral ruthenium-allenylidene complexes as key intermediates.