New insights into the functions of anthrax toxin
New insights into the functions of anthrax toxin
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DOI：
10.1017/s1462399406010714
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发表时间：
2006-04-11
影响因子：
6.2
通讯作者：
Bradley, Kenneth A.
中科院分区：
文献类型：
--
作者：
Banks, David J.;Ward, Sabrina C.;Bradley, Kenneth A.
炭疽病是由革兰氏阳性细菌炭疽杆菌引起的疾病。B分泌的两种毒素。炭疽-致死毒素（LT）和水肿毒素（OT）-对毒力有显著贡献。虽然这些毒素已经研究了半个世纪，最近的证据表明，LT和OT在感染过程中有几个角色，以前没有归因于他们。对毒素诱导效应而非靶细胞溶解的研究表明，LT和OT影响以前被认为对毒素不敏感的细胞类型。近年来发现了多种宿主因子对炭疽毒素具有敏感性，并且有证据表明炭疽毒素可能有助于宿主的定殖和入侵。此外，现在已知这些毒素会引起与炭疽有关的广泛的组织和器官病理生理学。总之，这些新的发现表明，炭疽毒素相关的发病机制比传统上认识到的要复杂得多。
Anthrax is the disease caused by the Gram-positive bacterium Bacillus anthracis. Two toxins secreted by B. anthracis-lethal toxin (LT) and oedema toxin (OT) - contribute significantly to virulence. Although these toxins have been studied for half a century, recent evidence indicates that LT and OT have several roles during infection not previously ascribed to them. Research on toxin-induced effects other than cytolysis of target cells has revealed that LT and OT influence cell types previously thought to be insensitive to toxin. Multiple host factors that confer sensitivity to anthrax toxin have been identified recently, and evidence indicates that the toxins probably contribute to colonisation and invasion of the host. Additionally, the toxins are now known to cause a wide spectrum of tissue and organ pathophysiologies associated with anthrax. Taken together, these new findings indicate that anthrax-toxin-associated pathogenesis is much more complex than has been traditionally recognised.