Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum
Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum
复制标题
元素饮食诱导大鼠十二指肠和空肠唾液粘蛋白杯状细胞增殖
DOI：
10.1080/09168451.2015.1006569
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Takashi Kondo & Tatsuya Morita
中科院分区：
文献类型：
--
作者：
Shingo Hino ;Ayano Ito ;Takashi Kondo & Tatsuya Morita
我们通过组织学研究了元素饮食 (ED) 对大鼠小肠杯状细胞特征的影响。对照组中磺粘蛋白杯状细胞在整个小肠中占主导地位，而 ED 组中唾液粘蛋白杯状细胞则出现在十二指肠和空肠中。接下来，我们研究了管腔渗透压与杯状细胞特征的可能相关性。 ED组的胃渗透压在生理范围内。同时，摄入高葡萄糖饮食会升高胃渗透压并增加十二指肠和空肠中唾液酸粘蛋白杯状细胞的数量。此外，事实证明，ED 中较低的硫含量与 ED 摄入的独特杯状细胞特征无关。归纳表明，高浓度低分子营养物质流入小肠可能与杯状细胞的改变有关，但这种改变不一定是由于ED摄入引起的胃渗透压的变化所致。
We histologically examined the effects of elemental diet (ED) on the goblet cell profile in the rat small intestine. The sulfomucin goblet cells were predominant throughout the small intestine in the control group, while sialomucin goblet cells were manifest in the duodenum and jejunum in the ED group. Next, we investigated the possible relevance of luminal osmolality to the goblet cell profile. Gastric osmolality in the ED group was within the physiological range. Meanwhile, ingestion of high glucose diet elevated gastric osmolality and increased the number of sialomucin goblet cells in the duodenum and jejunum. Further, it turned out that the lower sulfur contents in ED was not related to the unique goblet cell profile by ED ingestion. It is inductively suggested that the influx of high concentrations of low molecular nutrients into the small intestine could be associated with the goblet cell alteration, but the alteration was not necessarily due to the changes in the gastric osmolality by ED ingestion.