The Role of Glycoprotein H in Herpesvirus Membrane Fusion
The Role of Glycoprotein H in Herpesvirus Membrane Fusion
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DOI：
10.2174/092986609788681850
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Browne, H. M.
中科院分区：
文献类型：
--
作者：
Browne, H. M.
疱疹病毒与细胞膜融合以允许病毒进入的机制仍然相对不清楚。这个过程被证明是难以解开的，很大程度上是因为多个病毒包膜蛋白似乎协同起作用来介导融合事件。对于1型单纯疱疹病毒（HSV1），糖蛋白B、D和gHL异源二聚体都是融合所必需的，而所有其他疱疹病毒家族成员的融合过程都涉及gHL对应物。了解对融合至关重要的gH的功能域可能为设计特定的病毒进入肽抑制剂提供可能性，最近的进展突出了这种方法的潜在用途。这篇综述讨论了这些进展，并概述了这一不同病毒家族中不同成员的gH同源物之间的一些异同。
The mechanism by which herpesviruses fuse with cellular membranes to permit virus entry is still relatively poorly understood. This process is proving difficult to unravel, largely due to the fact that multiple viral envelope proteins appear to function in concert to mediate the fusion event. For Herpes Simplex Virus Type 1 (HSV1), glycoproteins B, D and the gHL heterodimer are all required for fusion, and gHL counterparts are involved in the fusion process of all other members of the herpesvirus family. An understanding of the functional domains of gH that are critical for fusion may offer the possibility of designing specific peptide inhibitors of virus entry, and recent progress has highlighted the potential usefulness of this approach. This review discusses these advances and outlines some of the similarities and differences between gH homologues of the different members of this diverse family of viruses.