Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing
Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing
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DOI：
10.1016/j.snb.2004.11.055
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发表时间：
2005-07-22
影响因子：
8.4
通讯作者：
Osaka, T
中科院分区：
文献类型：
--
作者：
Niwa, D;Omichi, K;Osaka, T
通过精确控制制造工艺，在同一衬底上形成了用各种功能性单分子层（如有机硅烷单分子层）修饰的场效应晶体管（FET）。该器件表现出典型的晶体管特性，在水溶液中具有良好的稳定性。氨基单分子层修饰的FET作为离子敏感FET，具有良好的pH敏感性为58 mV/pH，和全氟烷基单分子层修饰的FET作为参考器件。此外，具有固定在氨基修饰的栅电极上的酶的装置能够以64 mV/decade的高灵敏度检测痕量浓度（10（-9）至10（-6）M）的尿素。这些单分子层修饰的器件有望作为工作电极和参比电极应用于片上离子和生物传感。(c)2004 Elsevier B. V.保留所有权利。
Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10(-9) to 10(-6) M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing. (c) 2004 Elsevier B.V. All rights reserved.