Novel Approaches to Imaging Tumor Metabolism.
Novel Approaches to Imaging Tumor Metabolism.
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DOI：
10.1097/ppo.0000000000000111
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Keshari KR
中科院分区：
文献类型：
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作者：
Tee SS;Keshari KR
近年来，代谢研究领域出现了戏剧性的复苏，这得益于对代谢物和表型之间相互作用的新发现。代谢底物及其产物可以是包括癌症在内的多种病理学的生物标志物，但我们对其体内相互作用和途径的理解受到非侵入性成像方法的鲁棒性的阻碍。近30年来，随着体内代谢研究新技术的发展而不断发展。这些方法包括基于核的，主要是正电子发射断层扫描（PET）和磁共振成像（MRI），其中许多已被转移到临床。这篇综述的目的是介绍两个长期存在的成像策略，以及新的方法来研究扰动的代谢途径在设置的致癌作用。这将涉及使用超极化MRI研究的11C和18F以及13C标记的核探针的描述。强调每种方法的优点和缺点，本摘要的目的是为读者提供一个框架，询问他们感兴趣的系统中的代谢畸变。
The field of metabolism research has made a dramatic resurgence in recent years, fueled by a newfound appreciation of the interactions between metabolites and phenotype. Metabolic substrates and their products can be biomarkers of a wide range of pathologies, including cancer, but our understanding of their in vivo interactions and pathways has been hindered by the robustness of non-invasive imaging approaches. The last 3 decades have been flushed with the development of new techniques for the study of metabolism in vivo. These methods include nuclear based, predominantly positron emission tomography (PET) and magnetic resonance imaging (MRI), many of which have been translated to the clinic. The purpose of this review is to introduce both long standing imaging strategies as well as novel approaches to the study of perturbed metabolic pathways in the setting of carcinogenesis. This will involve descriptions of nuclear probes labeled with 11C and 18F as well 13C for study using hyperpolarized MRI. Highlighting both advantages and disadvantages of each approach, the aim of this summary is to provide the reader with a framework for interrogation of metabolic aberrations in their system of interest.