Feature-based Design of Bio-degradable Micro-patterned Structures
Feature-based Design of Bio-degradable Micro-patterned Structures
复制标题
基于特征的生物可降解微图案结构设计
DOI：
10.3722/cadaps.2009.661-671
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发表时间：
2009
影响因子：
--
通讯作者：
B. Koç
中科院分区：
文献类型：
--
作者：
I. Ozbolat;Michelle Marchany;J. Gardella;F. Bright;A. Cartwright;R. Hard;W. Hicks;B. Koç
摘要本文提出了一种新的基于特征的变分模型来控制生物降解过程，从而控制生物降解微结构的材料释放动力学。微结构的图案架构根据基于组织工程要求的微结构上的预定降解曲线而变化。最佳的图案架构产生的微结构与不同的几何特征和降解动力学。几个微图案的例子提供了不同的图案特征（PF）和降解profile，和他们的时间为基础的降解profile是基于开发的生物降解模型计算。实验研究的降解过程中也开发制造的微结构的生物降解材料进行比较开发的计算模型。
AbstractThis paper presents a novelfeature-based variational modeling to control the biodegradation process and thus material release kinetics of biodegradable microstructures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the microstructure with varying geometric features and degradation kinetics.Several micropattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.
影响因子：
14
作者：
Lu, L;Peter, SJ;Mikos, AG
通讯作者：
Mikos, AG