Saccadic eye movements in spinocerebellar degeneration ? correspondence to clinical manifestation
Saccadic eye movements in spinocerebellar degeneration ? correspondence to clinical manifestation
复制标题
脊髓小脑变性中的眼球扫视运动？
DOI：
10.1016/j.clinph.2018.02.096
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Terao Yasuo
中科院分区：
文献类型：
--
作者：
Inomata-Terada Satomi;Tokushige Shinichi;Matsuda Shunichi;Yugeta Akihiro;Hamada Masashi;Ugawa Yoshikazu;Terao Yasuo
目的小脑参与扫视运动的控制，但小脑疾病中扫视运动异常，特别是垂直方向的异常尚不完全清楚。为了澄清小脑的作用，我们研究了扫视遗传性脊髓小脑变性（SCD）与纯cerebellar presentation.MethodsSubjects 20 SCD患者（SCA6，31）和19个正常年龄匹配的对照。我们使用的视觉引导（VGS）和记忆引导的眼跳任务（MGS），其中目标提出了在8个可能的方向与45度分离，并记录眼跳与基于视频的eye tracker.ResultsIn SCA患者，潜伏期显着延迟主要是在垂直和倾斜的方向，这与SARA分数。在所有方向上，超调和下调的数量都与SARA得分相关。峰值速度没有变化，但从开始到扫视的峰值速度的时间较短，而从峰值速度到扫视结束的时间是long.ConclusionThe振幅和速度曲线的变化可能反映了异常输出从小脑核，而潜伏期延长的病理生理仍然难以捉摸。我们希望眼跳分析为客观评估SCD和其他神经系统疾病铺平道路。
ObjectivesThe cerebellum is implicated in the control of saccade but saccade abnormality in cerebellar disorders is not fully delineated, especially in the vertical directions. To clarify the role of the cerebellum, we studied saccades in hereditary spinocerebellar degeneration (SCD) with pure cerebellar presentation.MethodsSubjects were 20 SCD patients (SCA6, 31) and 19 normal age-matched controls. We used the visual guided (VGS) and memory guided saccade tasks (MGS) in which targets were presented in 8 possible directions with 45 degree separation, and recorded saccades with a video-based eye tracker.ResultsIn SCA patients, latency was significantly delayed mainly in vertical and oblique directions, which correlated with SARA scores. The number of both overshoot and undershoot increased correlatively with SARA scores in all directions. Peak velocity showed no change, but the time from the beginning to the peak velocity of the saccade was shorter, whereas the time from the peak velocity to the end of saccade was longer.ConclusionThe change in amplitude and velocity profile may reflect abnormal output from the cerebellar nuclei, whereas the pathophysiology of prolonged latency remains elusive. We hope the saccade analysis paves the way toward objective assessment of SCD and other neurological disorders.