Neurons in the dorsal motor nucleus of the vagus may integrate vagal and spinal information from the GI tract.
Neurons in the dorsal motor nucleus of the vagus may integrate vagal and spinal information from the GI tract.
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DOI：
10.1152/ajpgi.1995.268.5.g780
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发表时间：
1995-05
期刊：
影响因子：
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通讯作者：
W. Renehan;X. Zhang;W. Beierwaltes;R. Fogel
中科院分区：
文献类型：
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作者：
W. Renehan;X. Zhang;W. Beierwaltes;R. Fogel
先前的研究提供的证据表明，迷走神经背运动核（DMNV）中的副交感传出神经元的活动可能受到来自胃肠道（GI）的迷走神经传入或脊髓输入的影响。然而，关于这种输入的性质及其通过脑干的整合仍然存在许多问题。本研究旨在研究这一问题的一个重要方面：脊髓输入到脑干在DMNV中肠敏感神经元的反应特性的产生中的潜在贡献。使用成年大鼠的细胞内记录和标记技术，我们发现脊髓上行通路能够向 DMNV 传递低阈值和高阈值内脏信息。我们还确定，当脑干迷走神经传入被切断时，孤束核中的神经元无法对肠扩张做出反应，这表明脊髓投射直接终止于 DMNV 神经元。这些数据支持了一个新的假设，即伴随腹部内脏的脊髓传入神经能够对无害和有害的刺激做出反应。结果还表明，DMNV 中的神经元在内脏感觉信息整合中发挥着比之前认识到的更大的作用。
Previous investigations have provided evidence that the activity of parasympathetic efferent neurons in the dorsal motor nucleus of the vagus (DMNV) may be influenced by either vagal afferent or spinal input from the gastrointestinal (GI) tract. Many questions remain, however, regarding the nature of this input and its integration by the brain stem. The present study was designed to examine one important aspect of this issue: the potential contribution of the spinal input to the brain stem in the generation of the response properties of intestine-sensitive neurons in the DMNV. Using intracellular recording and labeling techniques in adult rats, we found that ascending spinal pathways were capable of conveying both low- and high-threshold visceral information to the DMNV. We also determined that the neurons in the nucleus of the solitary tract failed to respond to intestinal distention when the vagal afferents to the brain stem had been severed, suggesting that the spinal projections terminate directly on the DMNV neurons. These data lend support to the emerging hypothesis that the spinal afferents that accompany the abdominal splanchnics are capable of responding to both innocuous and noxious stimuli. The results also suggest that the neurons in the DMNV play a larger role in the integration of visceral sensory information than was previously realized.