Metabolic modulation of inflammation-induced activation of coagulation
Metabolic modulation of inflammation-induced activation of coagulation
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DOI：
10.1055/s-2008-1066020
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发表时间：
2008-02-01
影响因子：
5.7
通讯作者：
Stroes, Erik
中科院分区：
文献类型：
--
作者：
Levi, Marcel;Nieuwdorp, Max;Stroes, Erik
凝血和炎症之间的双向相互作用与全身炎症反应主导的各种疾病状态（如严重感染或慢性血管疾病）相关，受代谢因素调节。脂蛋白代谢的变化影响炎症诱导的凝血激活，这可能影响下游效应，包括器官功能障碍和存活。同样，葡萄糖和胰岛素似乎影响炎症诱导的凝血和纤溶作用。高胰岛素血症影响炎症诱导和组织因子驱动的凝血激活，而高胰岛素血症调节纤维蛋白溶解反应。有迹象表明，代谢因子在炎症和凝血中的这种调节作用也可能对各种疾病状态的临床结果产生影响。
The bidirectional interaction between coagulation and inflammation, which is relevant in various disease states that are dominated by systemic inflammatory responses, such as severe infection or chronic vascular disease, is modulated by metabolic factors. Changes in lipoprotein metabolism affect the inflammation-induced activation of coagulation, which may have impact on downstream effects, including organ dysfunction and survival. Likewise, glucose and insulin seem to influence inflammation-induced effects on coagulation and fibrinolysis. Hyperglycemia affects inflammation-induced and tissue factor-driven activation of coagulation, whereas hyperinsulinemia modulates the fibrinolytic response. There are indications that this modulatory role of metabolic factors in inflammation and coagulation may also have an impact on clinical outcome in various disease states.