Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions.
Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions.
复制标题
母婴关系。
DOI：
10.1056/nejm197611252952201
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
J. David
中科院分区：
文献类型：
--
作者：
R. Rocklin;J. Kitzmiller;C. Carpenter;Garovoy Mr;J. David
我们研究了一种免疫机制，可以解释母亲在怀孕期间明显的“耐受”状态。通过淋巴细胞迁移抑制因子的产生，证实了多胎妇女体外对父系异体抗原的细胞免疫反应性。正常多胎妇女血清中含有一种因子，该因子以特定的方式阻断母淋巴细胞对父抗原的迁移抑制因子的产生。阻断因子是一种IgG抗体，其活性被父系淋巴细胞吸收而不被汇集的人血小板吸收。我们在难以维持正常足月妊娠的妇女中测试了这种阻断因子的生物学重要性。我们的观察表明，经历特发性自然流产的妇女产生淋巴细胞迁移抑制因子到父亲的异体抗原，但他们的血清缺乏阻断因子。妊娠期间血清阻断因子的存在可能有助于胎儿作为同种异体移植的成功。
We investigated an immunologic mechanism that might explain the apparent "tolerant" state of the mother during pregnancy. Cellular-immune reactivity in vitro to paternal alloantigens was demonstrated in multigravid women by production of lymphocyte migration inhibitory factor. Serum from normal multigravid women contained a factor that blocked production of migration inhibitory factor by maternal lymphocytes to paternal antigens in a specific manner. The blocking factor was an IgG antibody whose activity was removed by absorption with paternal lymphocytes but not with pooled human platelets. We tested the biologic importance of this blocking factor in women who have difficulty maintaining a normal term pregnancy. Our observations indicate that women who experience idiopathic spontaneous abortions produce lymphocyte migration inhibitory factor to paternal alloantigens, but their serums lack the blocking factor. The presence of the serum blocking factor during pregnancy may contribute to the success of the fetus as an allograft.