Effect of Increasing Stent Length on 3-Year Clinical Outcomes in Women Undergoing Percutaneous Coronary Intervention With New-Generation Drug-Eluting Stents Patient-Level Pooled Analysis of Randomized Trials From the WIN-DES Initiative
Effect of Increasing Stent Length on 3-Year Clinical Outcomes in Women Undergoing Percutaneous Coronary Intervention With New-Generation Drug-Eluting Stents Patient-Level Pooled Analysis of Randomized Trials From the WIN-DES Initiative
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DOI：
10.1016/j.jcin.2017.11.020
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发表时间：
2018-01-08
影响因子：
11.3
通讯作者：
Mehran, Roxana
中科院分区：
文献类型：
--
作者：
Chandrasekhar, Jaya;Baber, Usman;Mehran, Roxana
本研究的目的是检验每例患者的支架长度和每处病变的支架长度是否是新一代药物洗脱支架（DES）经皮冠状动脉介入治疗（PCI）后女性3年结局的阴性标志。支架长度是否仍然与不良结局相关尚不清楚。（妇女在创新和药物洗脱支架）汇总数据库进行了评价。每例患者的总支架长度，在5，403名女性中可用（四分位数1，8 - 18 mm;四分位数2，18 - 24 mm;四分位数3，24 - 36 mm;四分位数4，>= 36 mm）和每个病变的支架长度，这在5，232名女性中可用（四分位数1，8至18 mm;四分位数2，18至20 mm;四分位数3，20至27 mm;四分位数4，>= 27 mm）以四分位数分析。主要终点是3年主要不良心血管事件（MACE），定义为全因死亡、心肌梗死或靶病变血运重建的复合事件。结果：在每例患者分析中，观察到3年MACE的校正风险随支架长度的增加而逐步增加（p趋势
OBJECTIVES The aim of this study was to examine whether stent length per patient and stent length per lesion are negative markers for 3-year outcomes in women following percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES).BACKGROUND In the era of advanced stent technologies, whether stent length remains a correlate of adverse outcomes is unclear.METHODS Women treated with new-generation DES in 14 randomized trials from the WIN-DES (Women in Innovation and Drug-Eluting Stents) pooled database were evaluated. Total stent length per patient, which was available in 5,403 women (quartile 1, 8 to 18 mm; quartile 2, 18 to 24 mm; quartile 3, 24 to 36 mm; quartile 4, >= 36 mm), and stent length per lesion, which was available in 5,232 women (quartile 1, 8 to 18 mm; quartile 2, 18 to 20 mm; quartile 3, 20 to 27 mm; quartile 4, >= 27 mm) were analyzed in quartiles. The primary endpoint was 3-year major adverse cardiovascular events (MACE), defined as a composite of all-cause death, myocardial infarction, or target lesion revascularization.RESULTS In the per-patient analysis, a stepwise increase was observed with increasing stent length in the adjusted risk for 3-year MACE (p for trend