The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population.
The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population.
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DOI：
10.3346/jkms.2009.24.s1.s50
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发表时间：
2009-01
影响因子：
4.5
通讯作者：
Kim S
中科院分区：
文献类型：
--
作者：
Chin HJ;Song YR;Kim HS;Park M;Yoon HJ;Na KY;Kim Y;Chae DW;Kim S
活性氧已被认为是高血压发病的一个重要因素。胆红素是由血红素加氧酶降解的血红素代谢产物之一，是一种有效的抗氧化剂。我们验证了血清胆红素水平对正常血压受试者高血压发病率的影响。我们以血清胆红素最高五分位数1.1 mg/dL为标准对1208名血压正常的受试者进行分组。胆红素< 1.1 mg/dL组高血压发生率高于胆红素≥1.1 mg/dL组（186/908 vs. 43/300, p=0.018）。Cox比例风险模型显示，与1组相比，2组高血压的相对危险度为0.71(95%可信区间为0.51 ~ 0.99),p=0.048。在按性别、吸烟和肝功能状况分层的组中，第2组显示女性和非吸烟者患高血压的风险较低。综上所述，血清胆红素浓度在生理范围内轻度升高与高血压发病率呈负相关。胆红素对高血压发展的影响在女性和非吸烟者中更为明显。
Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subjects. We grouped 1,208 normotensive subjects by the criterion of the highest quintile value of serum bilirubin, 1.1 mg/dL. The incidence of hypertension was higher in group 1 with bilirubin less than 1.1 mg/dL than in group 2 with bilirubin 1.1 mg/dL or more (186/908 vs. 43/300, p=0.018). The relative risk for hypertension was 0.71 (95% confidence interval, 0.51-0.99), p=0.048 in group 2 compared to group 1 by Cox's proportional hazard model. Among the groups stratified by gender, smoking, and liver function status, the group 2 showed a lower risk of hypertension in females and in non-smokers. In conclusion, a mild increase within the physiological range of serum bilirubin concentration was negatively correlated with the incidence of hypertension. The effect of bilirubin on the development of hypertension was more evident in females and in non-smokers.