Characterization of a human B lymphocyte-specific antigen.
Characterization of a human B lymphocyte-specific antigen.
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DOI：
10.4049/jimmunol.125.4.1678
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发表时间：
1980-10
影响因子：
4.4
通讯作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
中科院分区：
文献类型：
--
作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
用单抗鉴定和鉴定了人B淋巴细胞特异性抗原(B1)。通过间接免疫荧光、细胞毒性和定量吸收，在所有受试者中，约9%的外周血单核细胞和95%的血液和淋巴器官中的B细胞上存在B1。单核细胞、静息和活化的T细胞、零细胞以及T细胞和髓系来源的肿瘤均为B1阴性。B1不同于标准的B细胞表型标志，包括Ig和Ia抗原。去除外周血中的B1阳性群体，通过成熟为产生Ig的细胞，消除了所有能够或对商陆有丝分裂原有反应的B细胞。
A human B lymphocyte-specific antigen (B1) was identified and characterized by the use of a monoclonal antibody. By indirect immunofluorescence, cytotoxicity, and quantitative absorption, B1 was present on approximately 9% of the peripheral blood mononuclear cell fraction and >95% of B cells from blood and lymphoid organs in all individuals tested. Monocytes, resting and activated T cells, null cells, and tumors of T cell and myeloid origin were B1 negative. B1 was distinct from standard B cell phenotypic markers, including Ig and Ia antigen. Removal of the B1 positive population in peripheral blood eliminated all B cells capable or responding to pokeweed mitogen by maturation to Ig-producing cells.